Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Research Institute for Nanotechnology and Advanced Materials, Isfahan University of Technology, Isfahan 84156-83111, Iran; Research Institute for Biotechnology and Bioengineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Int J Biol Macromol. 2019 Oct 15;139:1263-1271. doi: 10.1016/j.ijbiomac.2019.08.123. Epub 2019 Aug 14.
Due to applications of silver nanoparticles (Ag NPs) especially in advanced science fields, it is important to produce Ag antibacterial nanocomposites with enhanced antibacterial activity and reusability. Over the past decade researches about natural polymers have emphasized the use of them as nanoparticles coating. In this work, a novel core-shell antibacterial agent was synthesized through a three-step procedure. FeO nanoparticles (FeO NPs) were synthesized and coated with a natural polymer called Alyssum homolocarpum seed gum (AHSG). Ag NPs were immobilized on the AHSG resulting in formation of the new nanocomposite with improved antimicrobial properties. The immobilization of Ag NPs prevents the release of toxic Ag ions. The FeO@AHSG@Ag nanocomposite could easily be separated from medium using an external magnetic field due to presence of the FeO superparamagnetic nanoparticles. The as-synthesized nanocomposite was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, vibrating sample magnetometer and dynamic light scattering. The results showed that the magnetic nanocomposite was synthesized and coated successfully. Finally, results of disk diffusion method demonstrated that the nanocomposite exhibits excellent antibacterial activity against gram-positive and gram-negative bacteria.
由于银纳米粒子（Ag NPs）的应用，特别是在先进的科学领域，生产具有增强的抗菌活性和可重复使用性的 Ag 抗菌纳米复合材料非常重要。在过去的十年中，关于天然聚合物的研究强调了将它们用作纳米粒子涂层的用途。在这项工作中，通过三步法合成了一种新型核壳抗菌剂。合成了 FeO 纳米粒子（FeO NPs）并涂覆了一种称为 Alyssum homolocarpum 种子胶（AHSG）的天然聚合物。Ag NPs 固定在 AHSG 上，形成具有改善的抗菌性能的新纳米复合材料。Ag NPs 的固定防止了有毒 Ag 离子的释放。由于存在 FeO 超顺磁纳米粒子，FeO@AHSG@Ag 纳米复合材料可以很容易地通过外部磁场从介质中分离出来。通过傅里叶变换红外光谱、扫描电子显微镜、透射电子显微镜、X 射线衍射、振动样品磁强计和动态光散射对合成的纳米复合材料进行了表征。结果表明，成功合成并涂覆了磁性纳米复合材料。最后，圆盘扩散法的结果表明，该纳米复合材料对革兰氏阳性菌和革兰氏阴性菌表现出优异的抗菌活性。
