Marchianò Verdiana, Salvador Maria, Moyano Amanda, Gutiérrez Gemma, Matos María, Yáñez-Vilar Susana, Piñeiro Yolanda, Rivas José, Martínez-García José C, Peddis Davide, Blanco-López Maria C, Rivas Montserrat, Ditaranto Nicoletta, Cioffi Nicola
Department of Physical and Analytical Chemistry, University of Oviedo, 33006 Oviedo, Spain.
Department of Physics and IUTA, University of Oviedo, 33204 Gijon, Spain.
Antibiotics (Basel). 2021 Jan 27;10(2):119. doi: 10.3390/antibiotics10020119.
The urgency for the availability of new antibacterial/disinfectant agents has become a worldwide priority. At the same time, along with the extensive use of other metal nanoparticles (NPs), the investigation of magnetic NPs (MNPs) in antibacterial studies has turned out to be an increasingly attractive research field. In this context, we present the preparation and characterization of superparamagnetic iron oxide NPs, electrodecorated with antimicrobial copper NPs, able to modulate the release of bioactive species not only by the NP's stabilizer, but also through the application of a suitable magnetic field. Antimicrobial synergistic CuNPs stabilized by benzalkonium chloride have been used in the current study. We demonstrate the successful preparation of Cu@FeO MNPs composites through morphological and spectroscopic results. Additionally, an extensive magnetic characterization is reported, along with hyperthermia-induced copper ionic release. On the basis of our results, we propose a new generation of antimicrobial magnetic nanomaterials, whose bioactivity can be also tuned by the application of a magnetic field.
新型抗菌/消毒剂的紧迫性已成为全球优先事项。与此同时，随着其他金属纳米颗粒（NPs）的广泛使用，磁性纳米颗粒（MNPs）在抗菌研究中的调查已成为一个越来越有吸引力的研究领域。在此背景下，我们展示了超顺磁性氧化铁纳米颗粒的制备和表征，该纳米颗粒用抗菌铜纳米颗粒进行了电极修饰，不仅能够通过纳米颗粒的稳定剂调节生物活性物质的释放，还能通过施加合适的磁场来调节。在本研究中使用了由苯扎氯铵稳定的抗菌协同铜纳米颗粒。我们通过形态学和光谱学结果证明了Cu@FeO MNPs复合材料的成功制备。此外，还报告了广泛的磁性表征以及热疗诱导的铜离子释放。基于我们的结果，我们提出了新一代抗菌磁性纳米材料，其生物活性也可以通过施加磁场来调节。
