Università Cattolica del Sacro Cuore, Institute of Internal Medicine and Geriatrics, 00168 Rome, Italy; Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
Università Cattolica del Sacro Cuore, Institute of Internal Medicine and Geriatrics, 00168 Rome, Italy; Applied Kinesiology Laboratory-LCA, School of Physical Education, University of Campinas, 13.083-851 Campinas, SP, Brazil.
Exp Gerontol. 2019 Oct 15;126:110692. doi: 10.1016/j.exger.2019.110692. Epub 2019 Aug 14.
Frailty encompasses several domains (i.e., metabolic, physical, cognitive). The multisystem derangements underlying frailty pathophysiology, its phenotypic heterogeneity, and the fluctuations of individuals across severity states have hampered a comprehensive appraisal of the condition. Circulating biomarkers emerged as an alleged tool for capturing this complexity and, as proxies for organismal metabolic changes, may hold the advantages of: 1) supporting diagnosis, 2) tracking the progression, 3) assisting healthcare professionals in clinical and therapeutic decision-making, and 4) verifying the efficacy of an intervention before measurable clinical manifestations occur. Among available analytical tools, metabolomics are able to identify and quantify the (ideally) whole repertoire of small molecules in biological matrices (i.e., cells, tissues, and biological fluids). Results of metabolomics analysis may define the final output of genome-environment interactions at the individual level. This entire collection of metabolites is called "metabolome" and is highly dynamic. Here, we discuss how monitoring the dynamics of metabolic profiles may provide a read-out of the environmental and clinical disturbances affecting cell homeostasis in frailty-associated conditions.
衰弱涵盖多个领域（即代谢、身体和认知）。衰弱病理生理学的多系统紊乱、其表型异质性以及个体在严重程度状态下的波动，阻碍了对该疾病的全面评估。循环生物标志物作为一种捕捉这种复杂性的工具出现，作为生物体代谢变化的代表，可能具有以下优势：1）支持诊断，2）跟踪进展，3）协助临床医生进行临床和治疗决策，以及 4）在可测量的临床表现出现之前验证干预措施的疗效。在可用的分析工具中，代谢组学能够识别和定量生物基质（即细胞、组织和生物液）中（理想情况下）所有小分子的组成。代谢组学分析的结果可以定义个体水平上基因组-环境相互作用的最终结果。这个代谢物的整体集合称为“代谢组”，且高度动态。在这里，我们讨论了监测代谢谱的动态如何为衰弱相关疾病中影响细胞内稳态的环境和临床干扰提供一个指示。
