社区范围内过量用药危机期间低屏障阿片类激动剂诊所的密度与非致命过量用药风险：一项空间分析。
Density of low-barrier opioid agonist clinics and risk of non-fatal overdose during a community-wide overdose crisis: A spatial analysis.
作者信息
Amram Ofer, Socías Eugenia, Nosova Ekaterina, Kerr Thomas, Wood Evan, DeBeck Kora, Hayashi Kanna, Fairbairn Nadia, Montaner Julio, Milloy M J
机构信息
British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada; Department of Medicine, BC Centre on Substance Use, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada; Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, United States.
British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada; Department of Medicine, BC Centre on Substance Use, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada.
出版信息
Spat Spatiotemporal Epidemiol. 2019 Aug;30:100288. doi: 10.1016/j.sste.2019.100288. Epub 2019 Jul 4.
OBJECTIVES
In recent years, North America has witnessed a spike in the number of overdoses (OD) and OD-related deaths. The aim of this study was to assess spatial correlates of OD risk in Vancouver, Canada.
METHODS
Data utilized for this study was from three open and ongoing prospective cohorts of people who use drugs (PWUDs) in Vancouver, Canada. Logistic regression analyses with generalized linear mixed-effects models (GLMM) was used to examine correlates of residing in areas characterized by high OD rates. Mapping was used to examine areas showing OD clusters.
RESULTS
We included 1336 PWUDs who resided in the downtown area. In multivariable analysis, higher availability of methadone clinics within walking distance, daily cocaine injectors and daily crack users had independent decreased odds of living within an OD cluster.
CONCLUSION
This study found that higher availability of methadone clinics was associated with decreased odds of living within OD clusters.
目的
近年来，北美地区药物过量（OD）及与OD相关的死亡人数激增。本研究旨在评估加拿大温哥华药物过量风险的空间关联因素。
方法
本研究使用的数据来自加拿大温哥华三个正在进行的开放前瞻性吸毒人群（PWUDs）队列。采用广义线性混合效应模型（GLMM）进行逻辑回归分析，以检验居住在药物过量率高的地区的相关因素。通过绘图来检查显示药物过量聚集的区域。
结果
我们纳入了1336名居住在市中心地区的吸毒人群。在多变量分析中，步行距离内美沙酮诊所数量较多、每日注射可卡因者和每日吸食快克者居住在药物过量聚集区的几率独立降低。
结论
本研究发现，美沙酮诊所数量较多与居住在药物过量聚集区的几率降低有关。
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