Sayin Volkan I, LeBoeuf Sarah E, Papagiannakopoulos Thales
Sahlgrenska Cancer Center, Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, SE-405 30 Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA; Perlmutter Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Trends Cancer. 2019 Aug;5(8):457-459. doi: 10.1016/j.trecan.2019.06.001. Epub 2019 Jun 27.
Lung cancer remains one of the most genetically complex, aggressive, and lethal solid malignancies. Understanding how distinct lung cancer mutations give rise to altered nutrient requirements and promote immune evasion in the context of a heterogeneous lung tumor microenvironment is vital for the development of novel personalized therapeutic strategies.
肺癌仍然是遗传复杂性最高、侵袭性最强且致死性最高的实体恶性肿瘤之一。了解不同的肺癌突变如何在异质性肺肿瘤微环境中导致营养需求改变并促进免疫逃逸，对于开发新型个性化治疗策略至关重要。
