氯氮平，21世纪颇具争议的抗精神病药物金标准：换用棕榈酸帕利哌酮三个月一次注射剂可改善难治性精神分裂症队列中的代谢状况并降低抗精神病药物等效剂量。 - Suppr

Clozapine, a controversial gold standard antipsychotic for the 21st century: Switching to paliperidone palmitate 3-monthly improves the metabolic profile and lowers antipsychotic dose equivalents in a treatment-resistant schizophrenia cohort.

作者信息

Martínez-Andrés Juan Andrés, García-Carmona Juan Antonio

机构信息

Long-stay Unit of Psychiatry, Luis Valenciano Residence Hospital, Murcia, Spain.

Unit of Acute Psychiatry, Reina Sofía University Hospital, Murcia, Spain; Service of Neurology, Santa Lucía University Hospital, Cartagena, Murcia, Spain.

出版信息

Schizophr Res. 2019 Oct;212:234-236. doi: 10.1016/j.schres.2019.08.001. Epub 2019 Aug 15.

DOI:10.1016/j.schres.2019.08.001

PMID:31421972

Abstract

摘要

相似文献

Clozapine, a controversial gold standard antipsychotic for the 21st century: Switching to paliperidone palmitate 3-monthly improves the metabolic profile and lowers antipsychotic dose equivalents in a treatment-resistant schizophrenia cohort.氯氮平，21世纪颇具争议的抗精神病药物金标准：换用棕榈酸帕利哌酮三个月一次注射剂可改善难治性精神分裂症队列中的代谢状况并降低抗精神病药物等效剂量。

Schizophr Res. 2019 Oct;212:234-236. doi: 10.1016/j.schres.2019.08.001. Epub 2019 Aug 15.

Switching from clozapine to paliperidone palmitate-3-monthly improved obesity, hyperglycemia and dyslipidemia lowering antipsychotic dose equivalents in a treatment-resistant schizophrenia cohort.从氯氮平转换为棕榈酸帕利哌酮 3 个月，可改善治疗抵抗性精神分裂症患者的肥胖、高血糖和血脂异常，降低抗精神病药物等效剂量。

Int Clin Psychopharmacol. 2020 May;35(3):163-169. doi: 10.1097/YIC.0000000000000300.

Clozapine and paliperidone palmitate antipsychotic combination in treatment-resistant schizophrenia and other psychotic disorders: A retrospective 6-month mirror-image study.氯氮平联合棕榈酸帕利哌酮治疗难治性精神分裂症及其他精神病性障碍：一项为期 6 个月的回顾性镜像研究。

Eur Psychiatry. 2020 Jul 16;63(1):e71. doi: 10.1192/j.eurpsy.2020.72.

[Thoughts on a favourable evolution of a COVID-19 in a patient with resistant schizophrenia and on a combination of clozapine and paliperidone palmitate].[关于一名耐药性精神分裂症患者COVID-19病情良好演变以及氯氮平与棕榈酸帕利哌酮联合使用的思考]

Encephale. 2020 Jun;46(3S):S126-S127. doi: 10.1016/j.encep.2020.05.009. Epub 2020 May 21.

Fluvoxamine augmentation in clozapine-resistant schizophrenia: an open pilot study.氟伏沙明增强氯氮平对难治性精神分裂症的疗效：一项开放性初步研究。

Biol Psychiatry. 1996 Oct 1;40(7):671-4. doi: 10.1016/0006-3223(96)00170-9.

Incident infection during the first year of treatment - A comparison of clozapine and paliperidone palmitate long-acting injection.第一年治疗期间的感染事件——氯氮平与棕榈酸帕利哌酮长效注射剂的比较。

J Psychopharmacol. 2022 Feb;36(2):232-237. doi: 10.1177/02698811211058973. Epub 2022 Jan 7.

[Augmentation of Clozapine With Paliperidone in Schizophrenia Patients With Partial Response to Treatment: A Case Series].[在对治疗部分反应的精神分裂症患者中用帕利哌酮增强氯氮平治疗：病例系列]

Turk Psikiyatri Derg. 2016 Spring;27(1):57-62.

Pharmacokinetic profile after multiple deltoid or gluteal intramuscular injections of paliperidone palmitate in patients with schizophrenia.精神分裂症患者接受帕利哌酮棕榈酸酯多次三角肌或臀肌肌内注射后的药代动力学特征。

Clin Pharmacol Drug Dev. 2015 Jul;4(4):270-8. doi: 10.1002/cpdd.144. Epub 2014 Aug 28.

A qualitative study of patient experience when switching from paliperidone palmitate once monthly (PP1M) to paliperidone palmitate three monthly (PP3M) long-acting injectable antipsychotic.一项关于患者从每月一次棕榈酸帕利哌酮（PP1M）换用每三个月一次棕榈酸帕利哌酮（PP3M）长效注射用抗精神病药物时的体验的定性研究。

Schizophr Res. 2019 Feb;204:443-444. doi: 10.1016/j.schres.2018.09.012. Epub 2018 Sep 18.

Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia.氨磺必利与氯氮平联合用于难治性精神分裂症患者。

Australas Psychiatry. 2004 Mar;12(1):74-6. doi: 10.1046/j.1039-8562.2003.02064.x.

引用本文的文献

Comparative effectiveness of long-acting injectable antipsychotics in a large naturalistic cohort across two European centers: Findings from the long-acting injectable antipsychotics collaborative (LAICO) study.长效注射用抗精神病药物在两个欧洲中心大型自然队列中的比较疗效：长效注射用抗精神病药物协作研究（LAICO）的结果

Neurosci Appl. 2022 Oct 8;1:100111. doi: 10.1016/j.nsa.2022.100111. eCollection 2022.

Preliminary data from a 4-year mirror-image and multicentre study of patients initiating paliperidone palmitate 6-monthly long-acting injectable antipsychotic: the Paliperidone 2 per Year study.一项针对开始使用棕榈酸帕利哌酮每6个月长效注射用抗精神病药物的患者进行的为期4年的镜像多中心研究的初步数据：每年2次帕利哌酮研究。

Ther Adv Psychopharmacol. 2023 Dec 26;13:20451253231220907. doi: 10.1177/20451253231220907. eCollection 2023.

Cumulative Clinical Experience of the Use of Paliperidone Palmitate 3-Monthly Long-Acting Injection in the Treatment of Schizophrenia: A Critical Appraisal.使用棕榈酸帕利哌酮三个月长效注射剂治疗精神分裂症的累积临床经验：一项批判性评估。

Drug Healthc Patient Saf. 2023 Sep 12;15:113-123. doi: 10.2147/DHPS.S339170. eCollection 2023.

Third-generation antipsychotics in patients with schizophrenia and non-responsivity or intolerance to clozapine regimen: What is the evidence?精神分裂症患者中对氯氮平治疗方案无反应或不耐受时使用第三代抗精神病药物：证据是什么？

Front Psychiatry. 2022 Nov 29;13:1069432. doi: 10.3389/fpsyt.2022.1069432. eCollection 2022.

Evaluation of Risk Factors Associated to Prescription of Benzodiazepines and its Patterns in a Cohort of Patients from Mental Health: A Real World Study in Spain.评估精神卫生患者中苯二氮䓬类药物处方及其模式相关的危险因素：西班牙的真实世界研究。

Psychopharmacol Bull. 2021 Jan 12;51(1):81-93.

Long-Acting Injectable Antipsychotics: Analysis of Prescription Patterns and Patient Characteristics in Mental Health from a Spanish Real-World Study.长效注射抗精神病药：西班牙真实世界研究中精神卫生领域处方模式和患者特征分析。

Clin Drug Investig. 2020 May;40(5):459-468. doi: 10.1007/s40261-020-00913-7.

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Clozapine, a controversial gold standard antipsychotic for the 21st century: Switching to paliperidone palmitate 3-monthly improves the metabolic profile and lowers antipsychotic dose equivalents in a treatment-resistant schizophrenia cohort.

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