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Clozapine, a controversial gold standard antipsychotic for the 21st century: Switching to paliperidone palmitate 3-monthly improves the metabolic profile and lowers antipsychotic dose equivalents in a treatment-resistant schizophrenia cohort.

作者信息

Martínez-Andrés Juan Andrés, García-Carmona Juan Antonio

机构信息

Long-stay Unit of Psychiatry, Luis Valenciano Residence Hospital, Murcia, Spain.

Unit of Acute Psychiatry, Reina Sofía University Hospital, Murcia, Spain; Service of Neurology, Santa Lucía University Hospital, Cartagena, Murcia, Spain.

出版信息

Schizophr Res. 2019 Oct;212:234-236. doi: 10.1016/j.schres.2019.08.001. Epub 2019 Aug 15.

DOI:10.1016/j.schres.2019.08.001
PMID:31421972
Abstract
摘要

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Clozapine, a controversial gold standard antipsychotic for the 21st century: Switching to paliperidone palmitate 3-monthly improves the metabolic profile and lowers antipsychotic dose equivalents in a treatment-resistant schizophrenia cohort.氯氮平，21世纪颇具争议的抗精神病药物金标准：换用棕榈酸帕利哌酮三个月一次注射剂可改善难治性精神分裂症队列中的代谢状况并降低抗精神病药物等效剂量。
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Switching from clozapine to paliperidone palmitate-3-monthly improved obesity, hyperglycemia and dyslipidemia lowering antipsychotic dose equivalents in a treatment-resistant schizophrenia cohort.从氯氮平转换为棕榈酸帕利哌酮 3 个月，可改善治疗抵抗性精神分裂症患者的肥胖、高血糖和血脂异常，降低抗精神病药物等效剂量。
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