Institute of Medical and Biomedical Education, St. George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.
Department of Cell and Developmental Biology, Biosciences, UCL, Gower St, London, WC1E 6BT, UK.
Hum Genet. 2019 Sep;138(8-9):993-1000. doi: 10.1007/s00439-019-02055-z. Epub 2019 Aug 17.
In this brief commentary, we provide some of our thoughts and opinions on the current and future use of zebrafish to model human eye disease, dissect pathological progression and advance in our understanding of the genetic bases of microphthalmia, andophthalmia and coloboma (MAC) in humans. We provide some background on eye formation in fish and conservation and divergence across vertebrates in this process, discuss different approaches for manipulating gene function and speculate on future research areas where we think research using fish may prove to be particularly effective.
在这篇简要的评论中，我们就当前和未来使用斑马鱼来模拟人类眼部疾病、剖析病理性进展以及深入了解人类小眼症、无眼症和虹膜脉络膜缺损（MAC）的遗传基础，提出了一些想法和观点。我们介绍了鱼类眼睛形成过程中的背景知识以及这一过程中脊椎动物的保守性和分化，并讨论了不同的基因功能操作方法，推测了我们认为鱼类研究可能特别有效的未来研究领域。
