Veratrine-induced membrane potential oscillation is still apparent after the muscle has been treated with 1 mM KCN, or 1 mM NaN3, or 0.2 mM DNP, to inhibit oxidative metabolism. 2. The frequency of the membrane potential oscillation decreases reversibly in response to 1 mM phlorrhizin either in Na- or Li-Ringer solution. 3. Veratrine causes no membrane potential oscillation but only depolarization in muscles pretreated with 0.5 mM iodoacetic acid, eventually a few abortive waves can be observed. Iodoacetic acid also abolishes oscillation which has already developed. 4. On the basis of the present data it is suggested that rhythmic changes of metabolism may be related to the oscillation of membrane potential.
摘要
在用1 mM氰化钾、1 mM叠氮化钠或0.2 mM 2,4-二硝基苯酚处理肌肉以抑制氧化代谢后，藜芦碱诱导的膜电位振荡仍然明显。2. 在钠或锂林格氏液中，膜电位振荡的频率会因1 mM根皮苷而可逆性降低。3. 藜芦碱在用0.5 mM碘乙酸预处理的肌肉中不会引起膜电位振荡，只会导致去极化，最终可观察到一些顿挫波。碘乙酸也会消除已经出现的振荡。4. 根据目前的数据，提示代谢的节律性变化可能与膜电位振荡有关。
