Dankó M, Cseri J, Varga E
Acta Physiol Acad Sci Hung. 1981;58(4):275-83.
The dependence of the membrane potential oscillation induced by cevadine on the actual transmembrane potential was studied in the frog sartorius muscle. 1. If the membrane potential oscillation is recorded for hours, its amplitude is seen to decrease slowly and smoothly and the membrane potential measured during the resting period among the waves of oscillation also decreases simultaneously. This means that the depolarization increases. 2. The increase of depolarization results not only in a decrease in the amplitude of the oscillation but the oscillation ceases between -40 and -55 mV as well. 3. The phenomenon reappears if the membrane is partially repolarized on a cevadine treated muscle fibre on which the membrane potential oscillation has already ceased as a consequence of the relatively marked depolarization. 4. Changing the membrane potential either to a value more positive than -40 mV, or to one more negative than -90 mV the developed oscillation activity may reversibly be suspended. 5. According to the above results, the amplitude of the membrane potential oscillation depends on the actual membrane potential. If other factors which may influence the oscillation parameters are unchanged, the relationship between the oscillation amplitude and the membrane potential can be characterized by a linear equation. In these cases there is a close correlation between the measured values and the calculated ones.
在青蛙缝匠肌中研究了瑟瓦定诱导的膜电位振荡对实际跨膜电位的依赖性。1. 如果记录膜电位振荡数小时，会观察到其振幅缓慢且平稳地下降，并且在振荡波之间的静息期测量的膜电位也同时下降。这意味着去极化增加。2. 去极化的增加不仅导致振荡振幅减小，而且振荡在 -40 至 -55 mV 之间也会停止。3. 如果在因相对明显的去极化而膜电位振荡已经停止的瑟瓦定处理的肌纤维上使膜部分复极化，该现象会再次出现。4. 将膜电位改变为比 -40 mV 更正的值或比 -90 mV 更负的值，已产生的振荡活动可能会可逆地暂停。5. 根据上述结果，膜电位振荡的振幅取决于实际膜电位。如果其他可能影响振荡参数的因素不变，振荡振幅与膜电位之间的关系可以用线性方程来表征。在这些情况下，测量值与计算值之间存在密切的相关性。
