印度北部昌迪加尔一家儿童福利院发生水痘机构性暴发。
Institutional outbreak of varicella in a child welfare institute in Chandigarh, North India.
作者信息
Singh Mini P, Rungta Tripti, Kumar Archit, Goyal Kapil, Bharti Bhavneet, Ratho R K
机构信息
Department of Virology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Department of Paediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
出版信息
Indian J Med Microbiol. 2019 Jan-Mar;37(1):24-28. doi: 10.4103/ijmm.IJMM_18_264.
INTRODUCTION
Varicella outbreaks are known to occur in developing nations as vaccine coverage is still low.
MATERIAL AND METHODS
In the present study, an institutional outbreak from Chandigarh, India, is reported wherein the utility of non-invasive samples such as saliva and urine was studied for the molecular diagnosis of varicella by conventional polymerase chain reaction (PCR), real-time PCR and real-time loop-mediated isothermal amplification (real-time LAMP).
RESULTS
The results of the present study showed that saliva and urine samples can be used for outbreak investigation of varicella compared to varicella-zoster virus DNA in vesicular swab samples with reasonable sensitivity.
CONCLUSION
Thus, molecular techniques may be useful in the early identification of the outbreak and timely isolation, and the treatment of cases can further prevent its spread.
引言
由于疫苗接种覆盖率仍然较低，水痘疫情在发展中国家时有发生。
材料与方法
在本研究中，报告了印度昌迪加尔的一次机构性疫情，其中研究了唾液和尿液等非侵入性样本通过常规聚合酶链反应（PCR）、实时PCR和实时环介导等温扩增（实时LAMP）进行水痘分子诊断的效用。
结果
本研究结果表明，与水疱拭子样本中的水痘带状疱疹病毒DNA相比，唾液和尿液样本可用于水痘疫情调查，具有合理的敏感性。
结论
因此，分子技术可能有助于早期识别疫情并及时隔离，对病例的治疗可进一步防止其传播。
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