Lang T, Cambien F, Richard J L, Darné B, Jacqueson A
INSERM U 258, unité d'épidémiologie cardio-vasculaire, hôpital Broussais, Paris.
Arch Mal Coeur Vaiss. 1988 Jun;81 Spec No:171-4.
The relationship between alcohol consumption (AC) has been repeatedly confirmed. However, the respective contribution of the various types of beverages has not been clearly established. The cross-sectional data of the initial examination of the Paris prospective study II of the GREA, concerning 4547 male civil servants were thus analysed. Among subjects without any antihypertensive medication, systolic (SBP) and diastolic (DBP) blood pressure were positively associated with total AC; the differences between the first and the fifth quintile were respectively 6 and 3 mmHg (p less than 0.01 for wine, beer and spirits consumption). Using a linear combination of wine, beer and spirits consumption significantly improved the prediction of BP, as compared to total AC (p less than 0.001). In the multivariate analysis including age and body mass index (BMI), the consumption of 40 ml of alcohol from beer was associated with an increase of 5.7 mmHg for SBP and 2.6 mmHg for DBP (p less than 0.001). The elevation was 2.3 (SBP, p less than 0.001) and 0.8 mmHg (DBP, p less than 0.01) for wine consumption. Spirits consumption was associated with DBP (1.4 mmHg, p less than 0.001), but not with SBP. In conclusion, a positive relationship was observed with each of the three types of alcoholic beverages studied; however, this association was more pronounced for beer than for the two other beverages.
饮酒量（AC）之间的关系已得到反复证实。然而，各类饮品各自的作用尚未明确确立。因此，对GREA巴黎前瞻性研究II初始检查的4547名男性公务员的横断面数据进行了分析。在未服用任何抗高血压药物的受试者中，收缩压（SBP）和舒张压（DBP）与总饮酒量呈正相关；第一和第五五分位数之间的差异分别为6 mmHg和3 mmHg（葡萄酒、啤酒和烈酒消费的p值均小于0.01）。与总饮酒量相比，使用葡萄酒、啤酒和烈酒消费的线性组合能显著改善血压预测（p值小于0.001）。在包括年龄和体重指数（BMI）的多变量分析中，饮用40毫升啤酒中的酒精与收缩压升高5.7 mmHg和舒张压升高2.6 mmHg相关（p值小于0.001）。饮用葡萄酒时收缩压升高2.3 mmHg（p值小于0.001），舒张压升高0.8 mmHg（p值小于0.01）。饮用烈酒与舒张压相关（1.4 mmHg，p值小于0.001），但与收缩压无关。总之，在所研究的三种酒精饮料中均观察到了正相关关系；然而，这种关联在啤酒中比在其他两种饮料中更为明显。
