Schröder Helmut, Masabeu Angels, Marti Maria Josep, Cols Montserrat, Lisbona Josep Maria, Romagosa Cristina, Carión Teresa, Vilert Esther, Marrugat Jaume
Lipids and Cardiovascular Epidemiology Research Unit, Institut Municipal d'Investigació Mèdica, Carrer Doctor Aiguader 80, Barcelona, Spain.
Nutr Metab Cardiovasc Dis. 2007 Oct;17(8):609-15. doi: 10.1016/j.numecd.2006.04.010. Epub 2006 Oct 30.
Coronary heart disease (CHD) is the leading cause of death in industrialized societies. Identifying and characterizing modifiable variables associated with CHD is an important issue for health policy. The aim of the present study was to analyze the association of non-fatal myocardial infarction with total alcohol consumption and type of alcoholic beverage consumed. Preference of the subjects' consumption for beer, wine, or spirits was set at 80% or more of total alcoholic beverage consumption.
A population-based case-control study (244 subjects and 1270 controls) was conducted. Male patients aged 25 to 74 years with first myocardial infarction (MI) were recruited in the same region as the healthy male controls, who were taken from a random sample representative of the Gerona population. Alcoholic beverage consumption during the preceding week was recorded. Multiple logistic regression analysis was performed to determine the association of alcohol consumption and non-fatal MI. Total alcohol consumption up to 30 g per day, adjusted for lifestyle and cardiovascular risk factors, was inversely associated (Odds ratio 0.14; 95% confidence interval 0.06-0.36) with the risk of non-fatal MI. Drinking up to 20 g of alcohol through wine, beer and spirits significantly decreased the adjusted risk of MI. Higher alcohol intake did not substantially reduce the risk. A preference for spirits was correlated with a significantly increased risk of non-fatal MI (P<0.05).
Moderate alcohol consumption, independent of the type of alcoholic beverage, was associated with non-fatal MI risk reduction.
冠心病（CHD）是工业化社会中主要的死亡原因。识别并描述与冠心病相关的可改变因素对于卫生政策而言是一个重要问题。本研究的目的是分析非致命性心肌梗死与总酒精摄入量及所饮用酒精饮料类型之间的关联。将受试者对啤酒、葡萄酒或烈酒的偏好设定为占酒精饮料总消费量的80%或更多。
开展了一项基于人群的病例对照研究（244名受试者和1270名对照）。在与健康男性对照相同的地区招募年龄在25至74岁之间首次发生心肌梗死（MI）的男性患者，健康男性对照取自代表赫罗纳人群的随机样本。记录前一周的酒精饮料消费量。进行多因素逻辑回归分析以确定酒精消费与非致命性心肌梗死之间的关联。在对生活方式和心血管危险因素进行调整后，每天总酒精摄入量达30克与非致命性心肌梗死风险呈负相关（比值比0.14；95%置信区间0.06 - 0.36）。通过葡萄酒、啤酒和烈酒摄入高达20克酒精可显著降低经调整后的心肌梗死风险。更高的酒精摄入量并未大幅降低风险。对烈酒的偏好与非致命性心肌梗死风险显著增加相关（P<0.05）。
适度饮酒，无论酒精饮料类型如何，均与非致命性心肌梗死风险降低相关。
