Singh Y, Chaudhary V K, Bhatnagar R, Misra U K
Department of Biochemistry, University of Delhi, India.
Biochem Int. 1988 Jul;17(1):1-8.
Feeding of rice diet reduced the food consumption and growth of rats. Hepatic Cytochrome P-450, NADPH Cytochrome c reductase and the activity of cytochrome P-450 dependent enzymes (Aniline hydroxylase, aminopyrine N-demethylase, p-nitroanisole O-demethylase) were also decreased by feeding rice diet. Supplementation of lysine and threonine to rice diet improved the activity of these enzymes. NADPH regeneration and microsomal phosphatidylcholine were reduced by feeding rice diet. The phenobarbitone induced sleeping time was decreased by supplementing rice diet with lysine and threonine. The effect of protein is probably partly attributed to changes in membrane phosphatidylcholine content and NADPH regeneration rate.
喂食大米日粮会降低大鼠的食物摄入量和生长速度。喂食大米日粮还会使肝脏细胞色素P-450、NADPH细胞色素c还原酶以及细胞色素P-450依赖性酶（苯胺羟化酶、氨基比林N-脱甲基酶、对硝基苯甲醚O-脱甲基酶）的活性降低。在大米日粮中补充赖氨酸和苏氨酸可提高这些酶的活性。喂食大米日粮会使NADPH再生和微粒体磷脂酰胆碱减少。在大米日粮中补充赖氨酸和苏氨酸可缩短苯巴比妥诱导的睡眠时间。蛋白质的作用可能部分归因于膜磷脂酰胆碱含量和NADPH再生率的变化。
