Yang Ji Hoon, Hwang Eun Ju, Moon Jungyoon, Yoon Ji Young, Kim Ji Won, Choi Sungjun, Cho Soo Ick, Suh Dae Hun
Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.
Acne, Rosacea, Seborrheic Dermatitis and Hidradenitis Suppurativa Research Laboratory, Seoul National University Hospital, Seoul, South Korea.
J Dermatolog Treat. 2021 May;32(3):297-301. doi: 10.1080/09546634.2019.1657792. Epub 2019 Oct 16.
Herbal extracts with fewer adverse effects can be an alternative to these drugs because they can target various molecular pathways of acne pathogenesis.
To evaluate the clinical efficacy of herbal extracts (mangosteen, , L., Thunb) for the treatment of mild to moderate acne vulgaris.
Sixty patients were randomized in a 1:1 ratio to receive blinded treatment with herbal extracts or vehicle for 8 weeks. Inflammatory and non-inflammatory acne lesion counts, Investigator's Global Assessment, patient's satisfaction and safety profiles were assessed. We also performed skin biopsy at baseline and week 8 to confirm immunological changes with immunohistochemistry staining.
By the end of the study period, both inflammatory and non-inflammatory acne lesion counts were significantly decreased in herbal extracts group (< .05). In immunohistochemistry staining, expressions of IL-1α, IL-8, and keratin 16 were significantly decreased in herbal extracts group compared to vehicle group from baseline to week 8. There was no serious adverse events in both groups.
This herbal extracts can be a new therapeutic option for patients with mild to moderate acne vulgaris who are reluctant to use drugs.
副作用较少的草药提取物可以成为这些药物的替代品，因为它们可以针对痤疮发病机制的各种分子途径。
评估草药提取物（山竹，，L.，Thunb）治疗轻度至中度寻常痤疮的临床疗效。
60名患者按1:1比例随机分组，接受草药提取物或赋形剂的盲法治疗8周。评估炎性和非炎性痤疮皮损计数、研究者整体评估、患者满意度和安全性。我们还在基线和第8周进行皮肤活检，通过免疫组织化学染色确认免疫变化。
在研究期结束时，草药提取物组的炎性和非炎性痤疮皮损计数均显著下降（<.05）。在免疫组织化学染色中，从基线到第8周，与赋形剂组相比，草药提取物组中IL-1α、IL-8和角蛋白16的表达显著降低。两组均无严重不良事件。
这种草药提取物可以成为不愿使用药物的轻度至中度寻常痤疮患者的一种新的治疗选择。
