N.O.D topia (GuangZhou) Biotechnology Co., Ltd., Guangzhou, China.
Simpcare (GuangZhou) Biotechnology Co., Ltd., Guangzhou, China.
J Cosmet Dermatol. 2024 Oct;23(10):3356-3365. doi: 10.1111/jocd.16394. Epub 2024 May 24.
Acne vulgaris, a common chronic dermatological condition worldwide, is associated with inflammatory response and Cutibacterium acnes. Individuals with acne vulgaris and sensitive skin have limited suitable treatments due to the skin irritation and side effects exhibited by current hydroxy acidic medications.
This study aimed to evaluate the synergistic effects of Guaiacum officinale (GO) and Rhodomyrtus Tomentosa (RT) extracts for treating acne vulgaris on sensitive skin by inhibiting inflammation.
The phytochemical constituents and antioxidant activity of GO and RT extracts were determined in vitro. The anti-inflammatory effects were investigated in peptidoglycan (PGN)-induced HaCaT cells. Further, a 28-day clinical trial was conducted involving 30 subjects with both sensitive skin and acne to evaluate the efficacy and subjects' satisfaction.
Total phenolics and flavonoids were detected in GO and RT extracts, the IC values for DPPH radical scavenging were 6.15 wt% and 0.76 wt%, respectively. The combination of GO and RT extracts at a 1:1 (v/v) ratio significantly decreased the expression of TLR-2 and TLR-4, as well as the secretion of IL-1α, IL-8, and TNF-α in PGN-induced HaCaT cells, by 2.30-7.93 times compared to GO extract alone (p < 0.05). Moreover, the cream containing 5 wt% the combination significantly improved facial acne and redness (p < 0.05). The number of comedones decreased by 50.00% and papules by 30.65% after 28 days of application. No adverse events were reported and 96.67% of the subjects were satisfied with the treatment.
The efficacy of the GO and RT extracts in synergistically suppressing inflammation, improving acne vulgaris, and reducing redness. The study offers an effective and non-irritant treatment for acne vulgaris in individuals with sensitive skin.
寻常痤疮是一种常见的慢性皮肤病，与炎症反应和痤疮丙酸杆菌有关。由于目前羟基酸性药物引起的皮肤刺激和副作用，患有寻常痤疮和敏感性皮肤的个体可选择的合适治疗方法有限。
本研究旨在评估绿花白千层（GO）和杨梅（RT）提取物协同抑制炎症治疗敏感性皮肤寻常痤疮的效果。
体外测定 GO 和 RT 提取物的植物化学成分和抗氧化活性。在肽聚糖（PGN）诱导的 HaCaT 细胞中研究抗炎作用。进一步，对 30 例敏感性皮肤合并痤疮患者进行了为期 28 天的临床试验，以评估疗效和患者满意度。
GO 和 RT 提取物中检测到总酚类和类黄酮，DPPH 自由基清除的 IC 值分别为 6.15wt%和 0.76wt%。GO 和 RT 提取物以 1:1（v/v）的比例组合使用，与单独使用 GO 提取物相比，显著降低了 TLR-2 和 TLR-4 的表达以及 PGN 诱导的 HaCaT 细胞中 IL-1α、IL-8 和 TNF-α的分泌，降低了 2.30-7.93 倍（p<0.05）。此外，含有 5wt%该组合的乳膏显著改善了面部痤疮和发红（p<0.05）。经过 28 天的应用，粉刺减少了 50.00%，丘疹减少了 30.65%。无不良反应发生，96.67%的患者对治疗满意。
GO 和 RT 提取物协同抑制炎症、改善寻常痤疮和减少发红的疗效。该研究为敏感性皮肤寻常痤疮患者提供了一种有效且无刺激性的治疗方法。
