Wu Zhao, Deng Xinyu, Hu Qichao, Xiao Xiaolin, Jiang Jing, Ma Xiao, Wu Mingquan
State Key Laboratory of Southwestern Chinese Medicine Resources, Department of Pharmacy, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Hospital of Chengdu University of Traditional Chinese Medicine, School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2021 Sep 1;12:714694. doi: 10.3389/fphar.2021.714694. eCollection 2021.
Thunb (; Saururaceae) is widely distributed in Asian regions. It plays an important role in traditional health care and disease treatment, as its aboveground stems and leaves have a long medicinal history in China and are used in the treatment of pneumonia and lung abscess. In clinical treatment, it can usually be combined with other drugs to treat dysentery, cold, fever, and mumps; additionally, is an edible plant. This review summarizes detailed information on the phytochemistry and pharmacological effects of . By searching the keywords " and lung", " and heart", " and liver", and " and inflammation" in PubMed, Web of Science and ScienceDirect, we screened out articles with high correlation in the past ten years, sorted out the research contents, disease models and research methods of the articles, and provided a new perspective on the therapeutic effects of . A variety of its chemical constituents are characteristic of medicinal plants, the chemical constituents were isolated from , including volatile oils, alkaloids, flavonoids, and phenolic acids. Flavonoids and volatile oils are the main active components. In pharmacological studies, showed organ protective activity, such as reducing the release of inflammatory factors to alleviate lung injury. Moreover, regulates immunity, enhances the immune barriers of the vagina, oral cavity, and intestinal tract, and combined with the antibacterial and antiviral activity of its extract, effectively reduces pathogen infection. Furthermore, experiments and showed significant anti-inflammatory activity, and its chemical derivatives exert potential therapeutic activity against rheumatoid arthritis. Antitumour action is also an important pharmacological activity of , and studies have shown that has a notable effect on lung tumour, liver tumour, colon tumour, and breast tumour. This review categorizes the biological activities of according to modern research papers, and provides insights into disease prevention and treatment of .
蕺菜（三白草科）广泛分布于亚洲地区。它在传统医疗保健和疾病治疗中发挥着重要作用，其地上茎和叶在中国有着悠久的药用历史，用于治疗肺炎和肺脓肿。在临床治疗中，它通常可与其他药物联合用于治疗痢疾、感冒、发热和腮腺炎；此外，蕺菜还是一种可食用植物。本综述总结了蕺菜的植物化学和药理作用的详细信息。通过在PubMed、Web of Science和ScienceDirect中搜索关键词“蕺菜与肺”“蕺菜与心脏”“蕺菜与肝脏”以及“蕺菜与炎症”，我们筛选出了过去十年中相关性较高的文章，梳理了文章的研究内容、疾病模型和研究方法，并为蕺菜的治疗作用提供了新的视角。其多种化学成分具有药用植物的特征，从蕺菜中分离出的化学成分包括挥发油、生物碱、黄酮类化合物和酚酸。黄酮类化合物和挥发油是主要的活性成分。在药理研究中，蕺菜表现出器官保护活性，如减少炎症因子的释放以减轻肺损伤。此外，蕺菜调节免疫力，增强阴道、口腔和肠道的免疫屏障，并结合其提取物的抗菌和抗病毒活性，有效减少病原体感染。此外，实验表明蕺菜具有显著的抗炎活性，其化学衍生物对类风湿性关节炎具有潜在的治疗活性。抗肿瘤作用也是蕺菜的一项重要药理活性，研究表明蕺菜对肺癌、肝癌、结肠癌和乳腺癌有显著疗效。本综述根据现代研究论文对蕺菜的生物活性进行了分类，并为蕺菜的疾病防治提供了见解。
