Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Research Center for Patient Safety, Mashhad University of Medical Sciences, Mashhad, Iran; Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Infect Genet Evol. 2019 Dec;76:104003. doi: 10.1016/j.meegid.2019.104003. Epub 2019 Aug 16.
Apoptosis is a universal cellular defense mechanism against senescent, damaged, genetically mutated, or virally-infected cells. It also is critical for the maintenance of liver health. Fas and FasL system act as a major death pathway that triggers apoptosis cascade in the liver. In this systematic review and meta-analysis, we aimed to investigate the relationship between four major polymorphisms of Fas and FasL genes with susceptibility to or clearance of HBV infection. All the eligible studies were extracted from PubMed and Scopus with no date and language restriction. ORs with 95% CIs were used to evaluate the strength of the association based on the following genetic models: (1) the allelic, (2) the homozygote, (3) the dominant, and (4) the recessive models. Totally 7 related articles were included in this meta-analysis; 5 studies of 7 related articles investigated FasL -844C/T (rs763110) polymorphism, 4 studies investigated FasL IVS2nt-124, 6 studies investigated Fas -670 A/G (rs1800682), and 4 studies investigated Fas -1377 A/G (rs2234767) polymorphism. This meta-analysis showed that there is no statistically significant association between the risk or clearance of HBV infection and four studied Fas and FasL polymorphisms in their allelic comparison or genetic models. Fas -670, Fas -1377, FasL -124, and FasL -844 polymorphisms did not show any significant association with the clearance or risk of HBV infection. Therefore, it seems that susceptibility to HBV infection or clearance of it is not affected by Fas and FasL genetic polymorphisms. But, to reach a definitive conclusion, further studies with a larger sample size of different ethnicity are still needed.
细胞凋亡是一种普遍的细胞防御机制，可抵抗衰老、受损、遗传突变或病毒感染的细胞。它对于维持肝脏健康也至关重要。Fas 和 FasL 系统作为主要的死亡途径，在肝脏中触发凋亡级联。在这项系统评价和荟萃分析中，我们旨在研究 Fas 和 FasL 基因的四个主要多态性与乙型肝炎病毒（HBV）感染易感性或清除之间的关系。所有符合条件的研究均从 PubMed 和 Scopus 提取，无日期和语言限制。基于以下遗传模型，使用 ORs 和 95%置信区间（CI）评估关联的强度：（1）等位基因，（2）纯合子，（3）显性和（4）隐性模型。共有 7 篇相关文章纳入本荟萃分析；7 篇相关文章中的 5 项研究探讨了 FasL-844C/T（rs763110）多态性，4 项研究探讨了 FasL-IVS2nt-124，6 项研究探讨了 Fas-670A/G（rs1800682），4 项研究探讨了 Fas-1377A/G（rs2234767）多态性。本荟萃分析表明，在等位基因比较或遗传模型中，Fas 和 FasL 四种研究多态性与 HBV 感染的风险或清除之间没有统计学显著关联。Fas-670、Fas-1377、FasL-124 和 FasL-844 多态性与 HBV 感染的清除或风险无显著关联。因此，乙型肝炎病毒感染的易感性或清除似乎不受 Fas 和 FasL 遗传多态性的影响。但是，为了得出明确的结论，仍需要进一步开展不同种族、更大样本量的研究。
