FAS/FASL基因多态性与胃癌风险的关联：一项荟萃分析。
Association between the FAS/FASL polymorphisms and gastric cancer risk: a meta-analysis.
作者信息
Tian Jing, Pan Feng, Li Jing, Ma Yan, Cen Han, Pan Hai-Feng, Pan Yue-Yin, Ye Dong-Qing
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
出版信息
Asian Pac J Cancer Prev. 2012;13(3):945-51. doi: 10.7314/apjcp.2012.13.3.945.
OBJECTIVE
FAS/FASL gene promoter polymorphisms have been repeatedly associated with gastric cancer risk, but findings are inconclusive across studies. To address a more precise estimation of the relationship, a meta-analysis was performed.
METHODS
Data were collected from the Pubmed, Medline and EMBASE databases, with the last report up to 1 December, 2011. Crude ORs with 95% CIs were used to assess the strength of the association by (1) the additive, (2) the codominant, (3) the dominant, and (4) the recessive models.
RESULTS
A total of seven studies, including six studies on FAS -1377G>A polymorphism, five studies on FAS -670A>G polymorphism, and six studies on FASL -844T>C polymorphism, were identified in the current meta-analysis. Overall, an association of FAS -1377G>A (AA versus GG: OR = 1.313, 95% CI = 1.045-1.650, Ph = 0.347, I2 = 10.8) and FASL -844T>C (CC versus TT: OR = 1.352, 95% CI = 1.043-1.752, Ph = 0.461, I2 = 0.0) polymorphisms with gastric cancer was found in the codominant model. However, we did not detect any association between gastric cancer and the FAS -670A>G polymorphism. In the subgroup analysis by ethnicity, similar elevated risks were also observed in Asian population for FAS -1377G>A (AA versus GG: OR = 1.309, 95% CI = 1.041- 1.646, Ph = 0.240, I2 = 27.3) and FASL -844T>C (CC versus TT: OR = 1.420, 95% CI = 1.081-1.865, Ph = 0.524, I2 = 0.0) polymorphisms.
CONCLUSIONS
This meta-analysis indicated that FAS -1377G>A and FASL -844T>C polymorphisms might be associated with gastric cancer risk.
目的
FAS/FASL基因启动子多态性与胃癌风险的关联已被反复研究，但各研究结果尚无定论。为更精确地评估二者关系，进行了一项荟萃分析。
方法
从PubMed、Medline和EMBASE数据库收集数据，截至2011年12月1日的最新报告。采用粗OR值及95%可信区间，通过（1）相加模型、（2）共显性模型、（3）显性模型和（4）隐性模型评估关联强度。
结果
本荟萃分析共纳入7项研究，其中6项关于FAS -1377G>A多态性，5项关于FAS -670A>G多态性，6项关于FASL -844T>C多态性。总体而言，在共显性模型中发现FAS -1377G>A（AA与GG相比：OR = 1.313，95%可信区间 = 1.045 - 1.650，P_h = 0.347，I² = 10.8）和FASL -844T>C（CC与TT相比：OR = 1.352，95%可信区间 = 1.043 - 1.752，P_h = 0.461，I² = 0.0）多态性与胃癌有关。然而，未发现胃癌与FAS -670A>G多态性之间存在关联。在按种族进行的亚组分析中，亚洲人群中FAS -1377G>A（AA与GG相比：OR = 1.309，95%可信区间 = 1.041 - 1.646，P_h = 0.240，I² = 27.3）和FASL -844T>C（CC与TT相比：OR = 1.420，95%可信区间 = 1.081 - 1.865，P_h = 0.524，I² = 0.0）多态性也有类似的风险升高。
结论
本荟萃分析表明，FAS -1377G>A和FASL -844T>C多态性可能与胃癌风险有关。
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