Khoubila Nisrine, Bendari Mounia, Hda Nezha, Lamchahab Mouna, Qachouh Meryem, Rachid Mohamed, Quessar Asmaa
Hematology and Pediatric Oncology Unit, University Hospital Ibn Rochd, 20 August 1953 Hospital, 6, Rue Lahcen EL Arjoune, Casablanca 20000, Morocco; Faculty of Medicine and Pharmacy of Casablanca. Casablanca Hassan II university, Morocco.
Hematology and Pediatric Oncology Unit, University Hospital Ibn Rochd, 20 August 1953 Hospital, 6, Rue Lahcen EL Arjoune, Casablanca 20000, Morocco; Faculty of Medicine and Pharmacy of Casablanca. Casablanca Hassan II university, Morocco.
Cancer Genet. 2019 Oct;238:1-9. doi: 10.1016/j.cancergen.2019.06.010. Epub 2019 Jun 15.
We analyzed the cytogenetic characteristics of a representative population of young adults with de novo acute myéloblastic leukemia (AML) treated in a single center institution.
Patients with de novo AML included were aged between 20 and 60 years. Cytogenetic analysis was done at diagnosis. Twenty cells were analyzed, although examination of lower numbers of metaphases was also acceptable if an abnormal clone was detected.
From 1/1/04 to 31/12/2014, among 1315 adult patients, 1055 (80%) patients were aged between 20 and 60 years. Karyotype was done in 927 (88%) patients and cytogenetic analysis failed in 32 cases (3·4%). Clonal abnormalities were observed in 520 (58%) patients. 175 (19·5%) were classified in the favorable group, 609 were in the intermediate group and 111 (12·5%) were in the adverse group. The most frequent chromosomal abnormality observed was t(8;21) in 112 (12·5%). Thirty three (3·7%) patients had t(15;17) and 30 (3·3%) had inv16, trisomy 8 was found in 47 (5·2%), 11q23 rearrangements in 32 (3·6%), 67 (7·4%) had a complex karyotype, -5/del(5q) and -7/del(7q) were seen in, respectively, 11(1%) and 27 (3%). Monosomy occurred in 115 (13%) patients, 70 (8%) responded to the definition of monosomal karyotypes.
This is the largest study done in Morocco, Africa and Middle East. Epidemiological studies involving different ethnic populations and geographic regions of the world should help unfold the true nature of environmental and genetic interplay in the development of AML. Our cytogenetic profile reveals some particularities when compared to other populations; it does not seem to be similar neither to eastern or western countries.
我们分析了在单一中心机构接受治疗的具有代表性的年轻成人新发急性髓系白血病（AML）患者群体的细胞遗传学特征。
纳入的新发AML患者年龄在20至60岁之间。在诊断时进行细胞遗传学分析。分析20个细胞，不过如果检测到异常克隆，检查较少数量的中期分裂相也是可以接受的。
从2004年1月1日至2014年12月31日，在1315例成年患者中，1055例（80%）患者年龄在20至60岁之间。927例（88%）患者进行了核型分析，32例（3.4%）细胞遗传学分析失败。520例（58%）患者观察到克隆性异常。175例（19.5%）被归类为预后良好组，609例为中间组，111例（12.5%）为预后不良组。观察到的最常见染色体异常是t(8;21)，共112例（12.5%）。33例（3.7%）患者有t(15;17)，30例（3.3%）有inv16，47例（5.2%）发现8号染色体三体，32例（3.6%）有11q23重排，67例（7.4%）有复杂核型，-5/del(5q)和-7/del(7q)分别见于11例（1%）和27例（3%）。115例（13%）患者出现单体型，70例（8%）符合单体型核型的定义。
这是在摩洛哥、非洲和中东地区开展的规模最大的研究。涉及世界不同种族人群和地理区域的流行病学研究应有助于揭示AML发生过程中环境与基因相互作用的真实本质。与其他人群相比，我们的细胞遗传学图谱显示出一些特殊性；它似乎与东方或西方国家都不相似。
