肥胖的糖尿病前期患者的维生素D水平与胰岛素抵抗相关吗？一项埃及多中心研究。

Does vitamin D status correlate with insulin resistance in obese prediabetic patients? An Egyptian multicenter study.

作者信息

Hetta Helal F, Fahmy Eman M, Mohamed Ghada A, Gaber Marwa A, Elkady Azza, Elbadr Mohamed M, Al-Kadmy Israa M S

机构信息

Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Department of Endocrinology, Faculty of Medicine, Helwan University, Egypt.

出版信息

Diabetes Metab Syndr. 2019 Sep-Oct;13(5):2813-2817. doi: 10.1016/j.dsx.2019.07.043. Epub 2019 Jul 29.

DOI:10.1016/j.dsx.2019.07.043

PMID:31425941

Abstract

BACKGROUND

The link between Vitamin-D deficiency and type 2 diabetes (T2D) is well-established. Since prediabetic obese populations have the greatest risk to develop to T2D, it was important in our study to examine serum 25(OH) D3 concentration among prediabetic obese patients and to evaluate the correlation between serum level of vitamin D and BMI, FBS, HOMA IR and HbA1c among prediabetes patients.

METHODS

A multicenter case control study was carried out among 101 prediabetic persons & 50 controls, after obtaining consent from subjects and clearance from institutional ethics committee. Serum vitamin D level, Plasma levels of glycosylated hemoglobin (HbA1c) and fasting insulin levels were measured by ELISA in both groups enrolled in the study.

RESULTS

The prevalence of vitamin-D deficiency/insufficiency was (73.3%) (n = 74) among 101 prediabetic obese individuals. Also, A significant inverse correlation was observed between vitamin D levels & body mass index(r = - 0.28, P = 0.004); fasting blood sugar (r = - 0.22, P = 0.002); HOMA insulin resistance (r = - 0.25 P = 0.01); HbA1C (r = - 0.2, P= 0.004).

CONCLUSIONS

High prevalence of vitamin D deficiency exists among obese prediabetic individuals and there is significant inverse correlation between BMI, FBS, HOMA IR, HbA1c and vitamin D level.

摘要

背景

维生素D缺乏与2型糖尿病（T2D）之间的联系已得到充分证实。由于糖尿病前期肥胖人群发展为T2D的风险最大，因此在我们的研究中，检测糖尿病前期肥胖患者的血清25(OH)D3浓度，并评估糖尿病前期患者血清维生素D水平与BMI、空腹血糖（FBS）、稳态模型评估胰岛素抵抗（HOMA IR）和糖化血红蛋白（HbA1c）之间的相关性非常重要。

方法

在获得受试者同意并经机构伦理委员会批准后，对101例糖尿病前期患者和50例对照者进行了一项多中心病例对照研究。通过酶联免疫吸附测定法（ELISA）测量了研究中两组的血清维生素D水平、糖化血红蛋白（HbA1c）血浆水平和空腹胰岛素水平。

结果

101例糖尿病前期肥胖个体中维生素D缺乏/不足的患病率为73.3%（n = 74）。此外，维生素D水平与体重指数（r = - 0.28，P = 0.004）、空腹血糖（r = - 0.22，P = 0.002）、HOMA胰岛素抵抗（r = - 0.25，P = 0.01）、HbA1C（r = - 0.2，P = 0.004）之间存在显著负相关。