Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Medicine (Baltimore). 2023 Nov 24;102(47):e36322. doi: 10.1097/MD.0000000000036322.
Vitamin D deficiency increases the risk of developing diabetes, dyslipidemia, and other chronic diseases. We aimed to investigate the relationship between vitamin D deficiency, glycemic levels, and lipid profiles in individuals with prediabetes and nondiabetes. This observational cross-sectional study was conducted on 249 adults who were divided into 2 groups based on the American Diabetes Association classification: nondiabetics and prediabetics. The serum vitamin D levels, lipid profiles, fasting blood glucose levels, hemoglobin A1c levels, fasting insulin levels, and insulin resistance (IR) were evaluated. The prevalence of vitamin D deficiency in all participants was 30.9%, and mean vitamin D levels were significantly [P = .0004] lower in prediabetics, who were more common in females. Furthermore, prediabetics had significantly higher serum triglycerides [P = .0006], and significantly lower serum high-density lipoprotein levels [P = .0148] than those nondiabetics. Serum cholesterol and low-density lipoprotein levels did not differ significantly between the 2 groups. 31.4% of all participants were overweight and 40.2% were obese. Furthermore, there was a strong correlation between vitamin D levels and IR and body mass indices ≥ 25 in prediabetics [r = -0.92] [P < .001]. Finally, vitamin D levels had a significant inverse relationship with glycemic parameters and IR, particularly in obese participants, but there was no significant relationship with lipid profile. In conclusion, vitamin D deficiency is common in females, regardless of whether they are prediabetics, but is more prevalent in prediabetics. Vitamin D deficiency is associated with high triglycerides and low high-density lipoprotein levels, but there were no significant changes in total cholesterol or low-density lipoprotein levels. Furthermore, vitamin D levels were negatively correlated with both fasting blood glucose and hemoglobin A1c levels, and its deficiency was strongly associated with IR especially in obese patients despite there being no significant correlation with blood lipids.
维生素 D 缺乏会增加患糖尿病、血脂异常和其他慢性病的风险。我们旨在研究维生素 D 缺乏、血糖水平和血脂谱在糖尿病前期和非糖尿病个体中的关系。这项观察性横断面研究纳入了 249 名成年人，他们根据美国糖尿病协会的分类分为两组：非糖尿病患者和糖尿病前期患者。评估了血清维生素 D 水平、血脂谱、空腹血糖水平、糖化血红蛋白水平、空腹胰岛素水平和胰岛素抵抗（IR）。所有参与者的维生素 D 缺乏患病率为 30.9%，且糖尿病前期患者的平均维生素 D 水平显著[P=0.0004]更低，且女性中更为常见。此外，糖尿病前期患者的血清甘油三酯显著升高[P=0.0006]，高密度脂蛋白水平显著降低[P=0.0148]，而非糖尿病患者。两组的血清胆固醇和低密度脂蛋白水平无显著差异。所有参与者中，31.4%超重，40.2%肥胖。此外，糖尿病前期患者中维生素 D 水平与 IR 和 BMI≥25 之间存在很强的相关性[r=-0.92] [P<0.001]。最后，维生素 D 水平与血糖参数和 IR 呈显著负相关，特别是在肥胖参与者中，但与血脂谱无显著关系。总之，无论是否患有糖尿病前期，女性中维生素 D 缺乏很常见，但在糖尿病前期患者中更为普遍。维生素 D 缺乏与高甘油三酯和低高密度脂蛋白水平相关，但总胆固醇或低密度脂蛋白水平无显著变化。此外，维生素 D 水平与空腹血糖和糖化血红蛋白水平呈负相关，其缺乏与 IR 密切相关，尤其是在肥胖患者中，尽管与血脂无显著相关性。
