在一家私人诊所中，BMI值低于25 Kg/M2的成年人身体脂肪百分比与胰岛素抵抗之间的关系。
Relationship between body fat percentage and insulin resistance in adults with Bmi values below 25 Kg/M2 in a private clinic.
作者信息
Zegarra-Lizana Paolo A, Ramos-Orosco Elizabeth J, Guarnizo-Poma Mirella, Pantoja-Torres Betzi, Paico-Palacios Socorro, Del Carmen Ranilla-Seguin Vitalia, Lazaro-Alcantara Herbert, Benites-Zapata Vicente A
机构信息
School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Sociedad Científica de Estudiantes de Medicina de la Universidad Peruana de Ciencias Aplicadas, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
Instituto Médico de la Mujer, Instituto Médico Metabólico, Lima, Peru.
出版信息
Diabetes Metab Syndr. 2019 Sep-Oct;13(5):2855-2859. doi: 10.1016/j.dsx.2019.07.038. Epub 2019 Jul 27.
AIM
To evaluate the association between elevated body fat percent (BF%) and the prevalence of insulin resistance (IR) in the adult population with body mass index (BMI) in the normal values.
METHODS
We carry out an analytical cross-sectional study. The participants attended outpatient from 2012 to 2016 in a private clinic in Lima-Peru between 18 and 60 years with a BMI between 19 and 24.9/Kg/m2. We defined elevated BF% if the values were greater than 25% in men and 30% in women and IR with a cut-off point of HOMA-IR based in the 75th percentile. We performed a generalized linear model from family Poisson (crude and adjusted) with robust standard errors to evaluate the association between BF% and the IR. We reported as association measure the prevalence ratio (PR) with their respective 95% confidence intervals (CI).
RESULTS
We included 284 participants, the average age was 33.77 ± 10.86 (SD) years and the percentage of women was 88.1%. The prevalence of elevated BF% was 71.13% and the prevalence of IR was 25%. We found an association between the elevated BF% and IR, PR = 3.17; 95% CI: 1.46-6.91.
CONCLUSIONS
Body fat percentage seems to be a good indicator of IR in patients with normal BMI and without endocrine comorbidities. Longitudinal prospective studies are recommended to corroborate our findings.
目的
评估正常体重指数（BMI）的成年人群中，体脂百分比（BF%）升高与胰岛素抵抗（IR）患病率之间的关联。
方法
我们开展了一项分析性横断面研究。研究对象为2012年至2016年期间在秘鲁利马一家私人诊所就诊的18至60岁门诊患者，其BMI在19至24.9/Kg/m²之间。若男性BF%值大于25%，女性大于30%，则定义为BF%升高；以基于第75百分位数的HOMA-IR为切点定义IR。我们采用具有稳健标准误的泊松族广义线性模型（粗模型和校正模型）来评估BF%与IR之间的关联。我们将患病率比（PR）及其各自的95%置信区间（CI）作为关联度量进行报告。
结果
我们纳入了284名参与者，平均年龄为33.77±10.86（标准差）岁，女性占比88.1%。BF%升高患病率为71.13%，IR患病率为25%。我们发现BF%升高与IR之间存在关联，PR = 3.17；95%CI：1.46 - 6.91。
结论
对于BMI正常且无内分泌合并症的患者，体脂百分比似乎是IR的一个良好指标。建议开展纵向前瞻性研究以证实我们的发现。
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