[不饱和脂质自动氧化诱导的吲哚环氧化。应用于人血清高密度和低密度脂蛋白的色氨酸残基]
[Oxidation of the indole ring induced by the auto-oxidation of unsaturated lipids. Application to tryptophan residues of high and low density lipoproteins of human serum].
作者信息
Reyftmann J P, Santus R, Mazière J C, Salmon S, Mazière C, Morlière P, Candide C
机构信息
Laboratoire de Physico-Chimie de l'Adaptation biologique, I.N.S.E.R.M. U. n. 312, Muséum national d'Histoire naturelle, Paris.
出版信息
C R Acad Sci III. 1988;307(14):745-8.
PMID:3142648
Abstract
Tryptophan residues are rapidly destroyed during Cu2+-catalyzed autoperoxidation of human serum lipoproteins. The same phenomenon occurs in the peroxidation of arachidonic acid incorporated into phosphatidylcholine liposomes using tryptophan, tryptamine and serotonin as oxidizable substrates. Replacing arachidonic acid by cholesterol inhibits the indole ring degradation.
摘要
在人血清脂蛋白的铜离子催化自过氧化过程中，色氨酸残基会迅速被破坏。在以色氨酸、色胺和血清素作为可氧化底物掺入磷脂酰胆碱脂质体中的花生四烯酸的过氧化过程中，也会出现同样的现象。用胆固醇替代花生四烯酸可抑制吲哚环的降解。
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