Radiotherapy Department, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu, PR China.
The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, Gansu, PR China.
Future Oncol. 2019 Sep;15(26):3081-3095. doi: 10.2217/fon-2019-0187. Epub 2019 Aug 20.
This Systematic Review summarizes the literatures of clinical trials on the efficacy and safety of carbon ion therapy for gynecological carcinomas. The protocol is detailed in the online PROSPERO database, registration no. CRD42019121424, and a final set of eight studies were included. In the treatment of cervical carcinomas, both carbon ion therapy alone and carbon ion therapy concurrent chemotherapy have presented good efficacy. Besides, the efficacy of inoperable endometrial carcinomas and gynecological melanoma are similar to that of surgical treatment. In terms of safety, gastrointestinal and genitourinary toxicities are low and could be controlled by limiting the volume and dose of intestinal tract and bladder. Carbon ion radiotherapy could be considered a safe, effective and feasible therapy for gynecological carcinomas.
本系统综述总结了关于碳离子治疗妇科癌症的疗效和安全性的临床试验文献。该方案在 PROSPERO 在线数据库中详细说明，注册号为 CRD42019121424，最终纳入了八项研究。在宫颈癌的治疗中，碳离子单独治疗和碳离子联合化疗均表现出良好的疗效。此外，无法手术的子宫内膜癌和妇科黑色素瘤的疗效与手术治疗相似。在安全性方面，胃肠道和泌尿生殖系统毒性较低，通过限制肠道和膀胱的体积和剂量可以控制。碳离子放射治疗可以被认为是一种安全、有效且可行的妇科癌症治疗方法。
