PTEN 在基质中。
PTEN in the Stroma.
机构信息
Department of Radiation Oncology and The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Hollings Cancer Center, Charleston, South Carolina 29425, USA.
出版信息
Cold Spring Harb Perspect Med. 2019 Oct 1;9(10):a036111. doi: 10.1101/cshperspect.a036111.
Although tremendous progress has been made in understanding the functions of (PTEN) in tumor cells, only recently have tumor cell-non-autonomous actions within the tumor microenvironment (TME) been appreciated. While it is accepted that the TME actively communicates with cancer cells to influence disease progression, our understanding of the genes and pathways responsible is still evolving. Given that inactivation of PTEN in the stroma is correlated with worse outcomes in human cancers, determining the unique functions and mechanisms of PTEN regulation in various TME cell compartments is essential. In this review, the evidence for PTEN function in different TME cell compartments, the mechanisms governing PTEN inactivation, and the downstream pathways regulated by PTEN that are critical for intracellular communication, are covered. The potential clinical implications of these findings as well as the future directions for the study of stromal PTEN are discussed.
尽管在理解肿瘤细胞中（PTEN）的功能方面已经取得了巨大进展，但直到最近，人们才开始认识到肿瘤微环境（TME）中肿瘤细胞非自主性的作用。虽然人们已经接受了 TME 与癌细胞积极沟通以影响疾病进展的观点，但我们对于负责这些作用的基因和途径的理解仍在不断发展。鉴于基质中 PTEN 的失活与人类癌症的预后更差相关，确定 PTEN 在各种 TME 细胞隔室中的独特功能和调节机制至关重要。在这篇综述中，涵盖了 PTEN 在不同 TME 细胞隔室中的功能、调控 PTEN 失活的机制以及受 PTEN 调控的对细胞内通讯至关重要的下游途径的证据。讨论了这些发现的潜在临床意义以及研究基质 PTEN 的未来方向。
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