Fogelman Nia, Canli Turhan
Department of Psychology, Stony Brook University, Stony Brook, NY, United States.
Front Psychol. 2019 Aug 2;10:1668. doi: 10.3389/fpsyg.2019.01668. eCollection 2019.
Early life stress (ELS) is a widely studied concept due to both its prevalent nature and its (presumed) detrimental consequences. In this review, we discuss the relationship between ELS and its underlying physiology spanning the sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and markers of inflammation related to immune function in both human and animal literature. We also consider the potential role of genetic and epigenetic factors on the ELS-health outcome relationship. We conclude with recommendations to overcome identified shortcomings in a field that seeks to address the health consequences of ELS.
早期生活压力（ELS）因其普遍存在的性质及其（假定的）有害后果而成为一个被广泛研究的概念。在本综述中，我们讨论了ELS与其潜在生理机能之间的关系，涵盖了交感神经系统、下丘脑 - 垂体 - 肾上腺轴以及人类和动物文献中与免疫功能相关的炎症标志物。我们还考虑了遗传和表观遗传因素在ELS与健康结果关系中的潜在作用。我们最后提出了一些建议，以克服该领域中已发现的不足，该领域旨在解决ELS对健康的影响。
