Schmitt C, Schmidt J, Wegener A, Hockwin O
Abteilung für Experimentelle Ophthalmologie der Universität, Bonn, Federal Republic of Germany.
Graefes Arch Clin Exp Ophthalmol. 1988;226(5):455-60. doi: 10.1007/BF02170008.
The effect of an aldose reductase inhibitor, AL-1576, on the development of UV-B and X-ray-induced cataract was studied with 100 female Brown-Norway rats. Histological studies were made with 32 eyes. A new histological procedure enabled detailed information on UV or X-ray-induced impairment on the lens, as well as on the potential efficiency of anticataract drugs. No definite effect of the aldose reductase inhibitor, AL-1576, on the development of UV or X-ray-induced cataract could be found. It may be concluded that AL-1576 cannot prevent damage caused by irradiation, like that of other oxidative influences. Disadvantageous effects of AL-1576 on the lens could be excluded.
用100只雌性棕色挪威大鼠研究了醛糖还原酶抑制剂AL-1576对紫外线B（UV-B）和X射线诱导白内障形成的影响。对32只眼睛进行了组织学研究。一种新的组织学方法能够提供关于紫外线或X射线对晶状体造成损伤的详细信息，以及抗白内障药物的潜在效果。未发现醛糖还原酶抑制剂AL-1576对紫外线或X射线诱导白内障的形成有明确影响。可以得出结论，AL-1576不能像其他氧化影响那样预防辐射造成的损伤。AL-1576对晶状体的不利影响可以排除。
