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[X射线诱导的白内障作为研究白内障发生机制的模型(作者译)]

[X-ray-induced cataract as a model for investigating cataractogenesis (author's transl)].

作者信息

Bergeder H D, Rink H, Hockwin O

出版信息

Klin Monbl Augenheilkd. 1982 Jan;180(1):13-6. doi: 10.1055/s-2008-1055003.

DOI:10.1055/s-2008-1055003
PMID:7077987
Abstract

X-rays are known to be a true cataractogenic agent. Since they can be accurately dosed and directed they are particularly suitable for inducing experimental cataracts. By means of ionizing rays, lesions are induced in various lens segments. Both the extent of the damage as well as the latency period until it becomes manifest are highly age-dependent. Since lens changes effected by ionizing rays are in many respects, similar to age-related changes, experimental cataracts induced by X-rays provide suitable models for investigating processes involved in the multifactorial genesis of senile cataract.

摘要

X射线是一种公认的真正致白内障因子。由于其剂量和照射方向可以精确控制,因此特别适合用于诱发实验性白内障。通过电离射线,可以在晶状体的不同部位诱发损伤。损伤的程度以及损伤显现出来的潜伏期都高度依赖于年龄。由于电离射线引起的晶状体变化在很多方面与年龄相关变化相似,因此X射线诱发的实验性白内障为研究老年性白内障多因素发病机制中涉及的过程提供了合适的模型。

相似文献

1
[X-ray-induced cataract as a model for investigating cataractogenesis (author's transl)].[X射线诱导的白内障作为研究白内障发生机制的模型(作者译)]
Klin Monbl Augenheilkd. 1982 Jan;180(1):13-6. doi: 10.1055/s-2008-1055003.
2
Development and repair of cataract induced by ultraviolet radiation.紫外线诱导白内障的发生与修复
Ophthalmic Res. 2000;32 Suppl 1:ii-iii; 1-44.
3
[Aging of the lens and cataract (author's transl)].[晶状体老化与白内障(作者译)]
Klin Monbl Augenheilkd. 1976 Aug;169(2):165-81.
4
TEMPOL protects against lens DNA strand breaks and cataract in the x-rayed rabbit.TEMPOL可保护经X射线照射的兔子晶状体免受DNA链断裂和白内障的影响。
Invest Ophthalmol Vis Sci. 1998 Mar;39(3):544-52.
5
Effect of gender on radiation-induced cataractogenesis.性别对辐射诱发白内障形成的影响。
Radiat Res. 2009 Jul;172(1):129-33. doi: 10.1667/RR1589.1.
6
Heavy-ion-induced cataractogenesis.重离子诱导的白内障发生
Aviat Space Environ Med. 1977 Aug;48(8):731-3.
7
Radiation cataractogenesis induced by neutron or gamma irradiation in the rat lens is reduced by vitamin E.维生素E可减轻大鼠晶状体因中子或γ射线照射引起的放射性白内障形成。
Scanning Microsc. 1990 Sep;4(3):641-9; discussion 649-50.
8
Ovarian hormone modulation of radiation-induced cataractogenesis: dose-response studies.卵巢激素对辐射诱导的白内障形成的调节作用:剂量反应研究
Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3304-10. doi: 10.1167/iovs.08-3262. Epub 2009 Feb 28.
9
Radiation cataractogenesis: a review of recent studies.辐射性白内障形成:近期研究综述
Radiat Res. 2009 Jul;172(1):1-9. doi: 10.1667/RR1688.1.
10
Radiation cataractogenesis in the amphibian lens.两栖动物晶状体的辐射性白内障形成
Ophthalmic Res. 1982;14(2):73-82. doi: 10.1159/000265177.

引用本文的文献

1
Effect of an aldose reductase inhibitor, AL-1576, on the development of UV-B and X-ray cataract.醛糖还原酶抑制剂AL-1576对UV-B和X射线诱导白内障形成的影响。
Graefes Arch Clin Exp Ophthalmol. 1988;226(5):455-60. doi: 10.1007/BF02170008.