新型抗肿瘤抗生素格利多菌素A、B和C。II. 结构解析。

Glidobactins A, B and C, new antitumor antibiotics. II. Structure elucidation.

作者信息

Oka M, Yaginuma K, Numata K, Konishi M, Oki T, Kawaguchi H

机构信息

Bristol-Myers Research Institute, Tokyo Research Center, Japan.

出版信息

J Antibiot (Tokyo). 1988 Oct;41(10):1338-50. doi: 10.7164/antibiotics.41.1338.

DOI:10.7164/antibiotics.41.1338

PMID:3142841

Abstract

The structures of new antitumor antibiotics, glidobactins A (Ia), B (Ib) and C (Ic) were elucidated by a combination of chemical and enzymatic degradations and spectral analyses. They have in common a cyclized tripeptide nucleus composed of L-threonine, 4(S)-amino-2(E)-pentenoic acid and erythro-4-hydroxy-L-lysine, and differ from each other in the unsaturated fatty acid moiety attached to the peptide.

摘要

通过化学和酶促降解以及光谱分析相结合的方法，阐明了新型抗肿瘤抗生素格列多菌素A（Ia）、B（Ib）和C（Ic）的结构。它们都有一个由L-苏氨酸、4(S)-氨基-2(E)-戊烯酸和赤藓糖型-4-羟基-L-赖氨酸组成的环化三肽核心，彼此的区别在于连接在肽上的不饱和脂肪酸部分。