Novel antibiotics, amythiamicins. II. Structure elucidation of amythiamicin D.
作者信息
Shimanaka K, Takahashi Y, Iinuma H, Naganawa H, Takeuchi T
机构信息
Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1994 Oct;47(10):1145-52. doi: 10.7164/antibiotics.47.1145.
PMID:7961165
Abstract
The structure of a unique polythiazole-containing cyclic peptide antibiotic, amythiamicin D, was elucidated by chemical degradations and NMR spectral analyses. Acid hydrolysis of amythiamicin D gave one mole of glycine and three new amino acids. Structures of N-acetyl-O-methyl derivatives of these new amino acids were determined by NMR and UV spectral analyses. Connectivities of these amino acids were determined by HMBC experiments.
摘要
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