Tran Maxine, Latifoltojar Arash, Neves Joana B, Papoutsaki Marianthi-Vasiliki, Gong Fiona, Comment Arnaud, Costa Ana S H, Glaser Matthias, Tran-Dang My-Anh, El Sheikh Soha, Piga Wivijin, Bainbridge Alan, Barnes Anna, Young Tim, Jeraj Hassan, Awais Ramla, Adeleke Sola, Holt Christopher, O'Callaghan James, Twyman Frazer, Atkinson David, Frezza Christian, Årstad Erik, Gadian David, Emberton Mark, Punwani Shonit
BJR Case Rep. 2019 May 2;5(3). doi: 10.1259/bjrcr.20190003. Epub 2019 Mar 5.
Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma (RCC) have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been explored. We report on the first-in-human non-invasive metabolic interrogation of RCC using hyperpolarized carbon-13 (C) magnetic resonance imaging (HP-MRI) and describe the validation of lactate metabolic heterogeneity against multi-regional mass spectrometry. HP-MRI provides an assessment of metabolism and provides a novel opportunity to safely and non-invasively assess cancer heterogeneity.
肿瘤内基因异质性以及代谢重编程在肾细胞癌（RCC）中的作用已得到广泛记载。然而，这些代谢变化在组织内的分布尚未得到探究。我们报告了首例使用超极化碳-13（C）磁共振成像（HP-MRI）对RCC进行的人体非侵入性代谢检测，并描述了针对多区域质谱法对乳酸代谢异质性的验证。HP-MRI可对代谢进行评估，并为安全、非侵入性地评估癌症异质性提供了新机会。
