Department of Health Sciences (DISSAL), Radiology Section, University of Genova, Via Pastore, 1-16132, Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Pathol Oncol Res. 2020 Jul;26(3):1483-1488. doi: 10.1007/s12253-019-00730-0. Epub 2019 Aug 20.
Aim of this study was to select all the cases of Primary (PBL) and Secondary (SBL) Breast Lymphoma from our breast unit since 01/01/2000, to obtain up-to-date data on the prevalence of this rare pathology and to analyze imaging features, with a special focus on CT. All pathological reports of breast biopsies performed from 01/01/2000 to 01/01/2019 were at first screened. Among them, we performed two different researches, looking for key words suggesting either a diagnosis of lymphoma or any other malignant disease. Using the Wiseman criteria, we identify PBL and SBL. All imaging features of PBL and SBL were analyzed. Prevalence of lymphoma amongst suspicious breast masses and amongst all breast malignancies were calculated. Out of 42,505 histopathology reports from mammary nodule biopsies, we found 19,354 malignancies. We were able to identify 11 patients affected by PBL (0,03% of suspicious breast lesions, 0.06% of breast malignancies), and 23 cases of SBL (0,05% of suspicious breast lesions, 0,12% of breast malignancies). Most common isotype in PBL was DLBC lymphoma, whereas in SBL that resulted Follicular lymphoma. In PBL group, we were able to retrieve images 7 CT or CT-PET study performed at diagnosis 7 US, 1 mammography and and 1 MR. In SBL group, we analyzed 14 CT/CT-PET examinations, 11 US studies and 3 mammography. PBL and SBL are rarer than considered until now. There is no definite imaging characteristic able to distinguish between these two pathologies and among them and breast cancer.
本研究的目的是从我们的乳腺科收集自 2000 年 1 月 1 日以来所有原发性（PBL）和继发性（SBL）乳腺淋巴瘤的病例，以获得有关这种罕见病理的最新数据，并分析影像学特征，特别关注 CT。首先筛选了从 2000 年 1 月 1 日至 2019 年 1 月 1 日进行的所有乳腺活检的病理报告。其中，我们进行了两项不同的研究，寻找暗示淋巴瘤或任何其他恶性疾病诊断的关键词。使用 Wiseman 标准，我们确定了 PBL 和 SBL。分析了 PBL 和 SBL 的所有影像学特征。计算了淋巴瘤在可疑乳腺肿块和所有乳腺恶性肿瘤中的患病率。在 42505 份乳腺结节活检的组织病理学报告中，我们发现了 19354 例恶性肿瘤。我们能够识别出 11 名患有 PBL 的患者（可疑乳腺病变的 0.03%，乳腺恶性肿瘤的 0.06%），以及 23 例 SBL（可疑乳腺病变的 0.05%，乳腺恶性肿瘤的 0.12%）。PBL 最常见的同种型是 DLBC 淋巴瘤，而 SBL 则是滤泡性淋巴瘤。在 PBL 组中，我们能够检索到 7 次 CT 或 CT-PET 检查，7 次 US，1 次乳房 X 线摄影和 1 次 MRI，这些都是在诊断时进行的。在 SBL 组中，我们分析了 14 次 CT/CT-PET 检查，11 次 US 研究和 3 次乳房 X 线摄影。PBL 和 SBL 比迄今为止认为的更为罕见。没有明确的影像学特征能够区分这两种病理学和它们与乳腺癌之间的区别。
