Al-Zaidi Rana Shaker, Al-Noor Nasir I
Department of Laboratory and Blood Bank, Anatomic Pathology Section, King Faisal Hospital, Makkah, Kingdom of Saudi Arabia.
Adv Biomed Res. 2021 Sep 29;10:26. doi: 10.4103/abr.abr_298_20. eCollection 2021.
Primary breast lymphomas are uncommon tumors and account for <1% of all malignant neoplasms of the breast. They are almost always of non-Hodgkin type, with B-cell lymphomas being the most common subtype. Anaplastic large cell lymphoma (ALCL) is a rare T-cell lymphoma that can involve the breast. Most of the articles in the literature describe ALCL in association with breast implants. We present a 48-year-old woman with a left breast enlargement and no history of an implant. Microscopic sections showed a high-grade CD30-positive lymphoid neoplasm with frequent giant cells, which turned out to be a primary ALCL of the breast, giant cell-rich pattern. To our knowledge, no cases of primary ALCL, giant cell-rich variant, have been reported in the breast in the absence of an implant making our case unique.
原发性乳腺淋巴瘤是罕见肿瘤，占所有乳腺恶性肿瘤的比例不到1%。它们几乎总是非霍奇金型，其中B细胞淋巴瘤是最常见的亚型。间变性大细胞淋巴瘤（ALCL）是一种可累及乳腺的罕见T细胞淋巴瘤。文献中的大多数文章描述的ALCL与乳房植入物有关。我们报告一名48岁女性，其左乳房肿大且无植入物病史。显微镜切片显示为高级别CD30阳性淋巴样肿瘤，有频繁的巨细胞，结果是乳腺原发性ALCL，富于巨细胞型。据我们所知，在无植入物的情况下，乳腺中尚未报道过原发性ALCL富于巨细胞变异型的病例，这使得我们的病例具有独特性。
