Rao T D, Rao P R
Department of Zoology, Osmania University, Hyderabad.
Indian J Lepr. 1988 Apr;60(2):189-95.
Serum estimations of immunoglobulins, complement components and their presence in circulating immune complexes were carried out in 39 Lepromatous, 44 ENL and 22 Post ENL leprosy patients. Serum IgG, IgA, IgM, C3 and C4 levels were determined by single radial immunodiffusion. Serum immune complexes were precipitated with Polyethylene Glycol (PEG) and IgG, IgA, IgM, C3 and C4 were estimated by single radial immunodiffusion and expressed as % of precipitation of their serum level. Decreased IgG, IgM; increased IgA and C3; and no change in C4 levels are observed in ENL than Lepromatous and Post ENL patients. However, a gradual insignificant reduction of IgG, IgA, and IgM was found from Lepromatous to ENL and Post ENL patients in the PEG-precipitates. Similarly, C3 and C4 was found reduced insignificantly in ENL than Lepromatous and Post ENL patients. The significance of these estimations in relation to immune status of ENL reactions are discussed.
对39例瘤型麻风、44例结节性红斑型麻风（ENL）和22例ENL后麻风患者进行了血清免疫球蛋白、补体成分及其在循环免疫复合物中存在情况的检测。采用单向免疫扩散法测定血清IgG、IgA、IgM、C3和C4水平。用聚乙二醇（PEG）沉淀血清免疫复合物，再通过单向免疫扩散法测定IgG、IgA、IgM、C3和C4，并以其血清水平沉淀百分比表示。与瘤型麻风及ENL后患者相比，ENL患者的IgG、IgM降低，IgA和C3升高，C4水平无变化。然而，在PEG沉淀物中，从瘤型麻风患者到ENL及ENL后患者，IgG、IgA和IgM逐渐出现轻微降低。同样，与瘤型麻风及ENL后患者相比，ENL患者的C3和C4也出现轻微降低。本文讨论了这些检测结果与ENL反应免疫状态的相关性。
