Serum immunoglobulin profile and C3 level in lepromatous leprosy patients.

A study of the serum levels of IgA, IgG, IgM and C3 in well defined cases of lepromatous leprosy has been undertaken. The serum levels of IgA, IgG and IgM were significantly raised in the group of lepromatous leprosy patients (20) compared to healthy controls (20). The C3 level also tends to be increased in these patients. In the 15 cases of LL, studied before and after ENL reaction, the levels of all the immunoglobulins as well as C3 were found to be further increased during ENL and showed a fall during subsidence.