Department of Otolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
DNA Cell Biol. 2019 Sep;38(9):915-921. doi: 10.1089/dna.2019.4744. Epub 2019 Aug 20.
Pharynx-larynx cancer is a complex malignant tumor with the sixth-highest morbidity and mortality rate worldwide. The telomerase reverse transcriptase gene, located on chromosome 5p15.33, plays a key role in the occurrence and progression of various cancer. The purpose of this hospital-based case-control study of patients in northern China was to explore the association between two single-nucleotide polymorphisms (SNPs) rs401681 in and rs2736100 in and the risk of head and neck cancer. We collected samples and relative characteristics and then analyzed the relationship between SNPs and pharynx-larynx cancer susceptibility by logistic regression analysis. The results suggested that the male patients carrying CT and CT+CC genotype model of rs401681 was associated with reduced risk of pharynx-larynx cancer compared with the CC genotype (adjusted odds ratios were 0.701 and 0.704, and 95% confidence intervals were 0.495-0.992 and 0.506-0.980; values were 0.045 and 0.038, respectively). In addition, we found that subjects with allele-C showed a relatively low risk of pharyngeal cancer when smoking exposure history was obtained. But the limitation is that in the future we need to further investigate about the exact functional effect of these two variant genes and a larger scale sample. Overall, in this research, our results show that the gene could be a meaningful biomarker for pharynx-larynx cancer susceptibility.
喉咽癌是一种复杂的恶性肿瘤，其发病率和死亡率在全球范围内位居第六。端粒酶逆转录酶基因位于 5p15.33 染色体上，在各种癌症的发生和发展中起着关键作用。本研究旨在探讨中国北方地区患者中位于基因上的两个单核苷酸多态性（SNPs）rs401681 和 rs2736100 与头颈部癌症风险之间的关联。我们收集了样本和相关特征，并通过逻辑回归分析来分析 SNPs 与喉咽癌易感性之间的关系。结果表明，与 CC 基因型相比，携带 CT 和 CT+CC 基因型模型的男性患者患喉咽癌的风险降低（调整后的比值比分别为 0.701 和 0.704，95%置信区间分别为 0.495-0.992 和 0.506-0.980；P 值分别为 0.045 和 0.038）。此外，我们发现，在考虑到吸烟史的情况下，具有等位基因-C 的个体患咽癌的风险相对较低。但存在的局限性在于，未来我们需要进一步研究这两个变异基因的确切功能效应和更大规模的样本。总的来说，在这项研究中，我们的结果表明基因可能是喉咽癌易感性的一个有意义的生物标志物。
