Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany.
Department of Developmental Biology of Vertebrates, Institute for Cell Biology and Neuroscience, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.
Curr Opin Genet Dev. 2019 Aug;57:54-60. doi: 10.1016/j.gde.2019.06.013. Epub 2019 Aug 18.
Collective cell migration plays essential roles in embryogenesis and also contributes to disease states. Recent years have seen immense progress in understanding mechanisms and overarching concepts of collective cell migration. Self-organization of moving groups emerges as an important common feature. This includes self-generating gradients, internal chemotaxis or mechanotaxis and contact-dependent polarization within migrating cell groups. Here, we will discuss these concepts and their applications to classical models of collective cell migration. Further, we discuss new models and paradigms of collective cell migration and elaborate on open questions and future challenges. Answering these questions will help to expand our appreciation of this exciting theme in developmental cell biology and contribute to the understanding of disease states.
细胞集体迁移在胚胎发生中起着至关重要的作用，也有助于疾病状态。近年来，人们在理解细胞集体迁移的机制和总体概念方面取得了巨大进展。移动群体的自我组织是一个重要的共同特征。这包括自我产生的梯度、内部趋化性或机械趋化性以及迁移细胞群体中的接触依赖性极化。在这里，我们将讨论这些概念及其在经典的细胞集体迁移模型中的应用。此外，我们还讨论了细胞集体迁移的新模型和范例，并详细阐述了悬而未决的问题和未来的挑战。回答这些问题将有助于我们更深入地了解发育细胞生物学中这一令人兴奋的主题，并有助于我们理解疾病状态。
