The Alan Edwards Centre for Research on Pain, McGill Univeristy, Montreal, QC, Canada.
Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, QC, Canada.
J Neuroimmunol. 2019 Oct 15;335:577017. doi: 10.1016/j.jneuroim.2019.577017. Epub 2019 Aug 2.
Human cytomegalovirus (CMV) infection is asymptomatic in immunocompetent individuals. However, it can lead to disease in immunodeficient population. Little is known of the mechanisms underlying the pathogenicity of the virus. We investigated the impact of CMV infection on mouse nervous system. Peripheral nerves but not spinal cord was permissive to MCMV during acute infection. Activated CD8 T cells, monocytes/macrophages and cytokine expression were increased in the blood and sciatic nerves of infected mice, which exhibited transient sensory dysfunction. This study indicates that systemic MCMV infection leads to a dissemination of MCMV into peripheral nerves, which is associated with a local inflammation but not nerve tissue damage in the acute phase.
人巨细胞病毒（CMV）感染在免疫功能正常的个体中无症状。然而，它可导致免疫缺陷人群发病。该病毒的致病机制知之甚少。我们研究了 CMV 感染对小鼠神经系统的影响。在急性感染期间，CMV 可感染外周神经，但不能感染脊髓。感染小鼠的血液和坐骨神经中，激活的 CD8 T 细胞、单核细胞/巨噬细胞和细胞因子表达增加，表现出短暂的感觉功能障碍。本研究表明，全身性 MCMV 感染可导致 MCMV 扩散到外周神经，这与急性炎症相关，而与神经组织损伤无关。
