Parquet A, Boneu B, Bosser C, Cazenave J P, Dirat G, Gazengel G, Grunebaum L, Sultan Y, Verroust F, Wiesel M L
Centre Régional de Transfusion Sanguine, Lille, France.
Nouv Rev Fr Hematol (1978). 1988;30(4):205-7.
The efficiency of heat treatment procedures of factor VIII and factor IX concentrates, prepared from voluntary, non-paid donors by three French Blood Transfusion Centres, on the inactivation of HIV and non-A, non-B hepatitis (NANB) viruses was assessed. Some 43 patients (26 haemophilia A, 17 haemophilia B) were followed for at least 1 year by testing for HIV antibodies and alanine aminotransferase (ALT). No HIV seroconversion was observed indicating that heat treatment was completely efficient. Among 26 haemophiliacs, 6 (4 haemophilia A, 2 haemophilia B) presented an elevation in ALT, indicating only a 75% reduction of NANB viral contamination.
对法国三个输血中心从自愿无偿献血者中采集制备的凝血因子VIII和凝血因子IX浓缩物的热处理程序在灭活HIV和非甲非乙型肝炎（NANB）病毒方面的效率进行了评估。通过检测HIV抗体和丙氨酸转氨酶（ALT），对约43名患者（26名甲型血友病患者、17名乙型血友病患者）进行了至少1年的随访。未观察到HIV血清转化，表明热处理完全有效。在26名血友病患者中，6名（4名甲型血友病患者、2名乙型血友病患者）ALT升高，表明NANB病毒污染仅减少了75%。
