Pollmann H
Hämophilie-Zentrum der Universitäts-Kinderklinik Münster.
Infusionsther Transfusionsmed. 1994 Aug;21 Suppl 1:80-3.
Based on the results of seven ICTH-controlled PUP studies only the virus-inactivating procedures by pasteurization (60 degrees C for 10 h), tri-n-butyl-phosphate/detergent treatment, and vapor heating (60 degrees C for 10 h and 1,200 mbar) have prevented the haemophilic patients from infections with hepatitis B, C and HIV. After the disaster of the HIV infection in haemophilic patients at the beginning of the 80's the factor concentrates given today seem to be safe for virus infections during substitution therapy. To prove this high therapeutical standard there is a need for a prospective long-term pharmaco-vigilance study under the auspices of an independent body such as the Medical Advising Committee of the National Haemophilia Society or other scientific organisations.
基于七项免疫交叉对照血浆研究的结果，只有巴氏灭菌法（60摄氏度，10小时）、磷酸三正丁酯/去污剂处理以及蒸汽加热（60摄氏度，10小时，1200毫巴）这些病毒灭活程序能防止血友病患者感染乙肝、丙肝和艾滋病毒。在80年代初血友病患者发生艾滋病毒感染的灾难之后，如今所使用的凝血因子浓缩剂在替代治疗期间似乎对病毒感染是安全的。为证明这一高治疗标准，需要在诸如国家血友病协会医学咨询委员会或其他科学组织等独立机构的主持下进行一项前瞻性长期药物警戒研究。
