Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA
Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Diabetes. 2019 Sep;68(9):1709-1716. doi: 10.2337/db19-0098.
There is wide variance among individuals in the fraction of insulin cleared by the liver (20% to 80%). Hepatic insulin clearance is 67% lower in African Americans than European Americans. Clearance is also lower in African American children 7-13 years of age. Lower hepatic insulin clearance will result in peripheral hyperinsulinemia: this exacerbates insulin resistance, which stresses the β-cells, possibly resulting in their ultimate failure and onset of type 2 diabetes. We hypothesize that lower insulin clearance can be a primary cause of type 2 diabetes in at-risk individuals.
个体肝脏清除的胰岛素比例(20% 至 80%)差异很大。非裔美国人的肝胰岛素清除率比欧洲裔美国人低 67%。7-13 岁的非裔美国儿童的清除率也较低。较低的肝胰岛素清除率将导致外周高胰岛素血症:这会加剧胰岛素抵抗,从而对β细胞造成压力,可能导致其最终衰竭并引发 2 型糖尿病。我们假设较低的胰岛素清除率可能是高危个体 2 型糖尿病的主要原因。