Abbot Samuel, Bossingham David, Proudman Susanna, de Costa Caroline, Ho-Huynh Albert
College of Medicine & Dentistry, James Cook University, Cairns, Queensland, Australia.
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Rheumatol Adv Pract. 2018 Oct 11;2(2):rky041. doi: 10.1093/rap/rky041. eCollection 2018.
Although numerous studies have investigated the roles of various genetic, epigenetic and environmental factors that may impact its aetiology, SSc is still regarded as an idiopathic disease. Given that there is significant heterogeneity in what has been proposed to influence the development of SSc, this systematic review was conducted to assess the impacts of different factors on the aetiology of scleroderma.
The search was performed in the PubMed, CINAHL and SCOPUS databases on 17 May 2017. Any study that made explicit reference to scleroderma or SSc that had information about the risk factors or epidemiology of the disease was included. The extracted outcome variables were prevalence, gender preponderance, geographical distribution, family history and various proposed environmental risk factors.
One thousand five hundred and seventy-four articles were screened for eligibility. Thirty-four articles were eligible for the systematic literature review.
Age between 45 and 64 years, female sex, positive family history and exposure to silica were found to be risk factors. There were conflicting findings regarding the impact of exposure to organic solvents and microchimerism. No relationship between infectious agents, alcohol consumption or cigarette smoking and the development of SSc was identified.
尽管众多研究已探究了各种可能影响硬皮病病因的遗传、表观遗传和环境因素的作用，但硬皮病仍被视为一种特发性疾病。鉴于在影响硬皮病发展的因素方面存在显著异质性，开展了这项系统评价以评估不同因素对硬皮病病因的影响。
于2017年5月17日在PubMed、CINAHL和SCOPUS数据库中进行检索。纳入任何明确提及硬皮病或系统性硬化症且包含有关该疾病危险因素或流行病学信息的研究。提取的结果变量包括患病率、性别优势、地理分布、家族史以及各种提出的环境危险因素。
筛选了1574篇文章以确定其是否符合纳入标准。34篇文章符合系统文献综述的要求。
发现年龄在45至64岁之间、女性、家族史阳性以及接触二氧化硅是危险因素。关于接触有机溶剂和微嵌合体的影响存在相互矛盾的研究结果。未发现感染因子、饮酒或吸烟与硬皮病发展之间存在关联。
