[结直肠癌的术前和术后辅助化疗。第1部分。服用优福定后组织中的药物浓度]
[Pre- and post-operative adjuvant chemotherapy of colorectal cancer. Part 1. Drug concentration in tissues following UFT administration].
作者信息
Tomita M, Shimoyama T, Hirano T, Nakagoe T, Shimizu T, Kusano H, Fukuda Y, Eida K, Ishii T, Kotake Y
机构信息
1st Dept. of Surgery, School of Medicine Nagasaki University.
出版信息
Gan To Kagaku Ryoho. 1988 Dec;15(12):3239-43.
The concentration of Tegafur, 5-FU and Uracil in tumor and normal tissue were measured in 47 colorectal cancer patients who had been administered UFT (400/mg) for seven days before operation. The concentration of Tegafur, 5-FU and Uracil in tumor was higher than in normal tissue (p less than 0.01), and the concentration of 5-FU was correlative to the concentration of Tegafur and Uracil in both tissues. The Dukes group and histological type were not related to the concentration of Tegafur, 5-FU and Uracil in either tissue. The uptake of each drug was good and high in tumor tissue.
对47例在手术前7天接受优福定（400毫克）治疗的结直肠癌患者，测定其肿瘤组织和正常组织中替加氟、5-氟尿嘧啶和尿嘧啶的浓度。肿瘤组织中替加氟、5-氟尿嘧啶和尿嘧啶的浓度高于正常组织（p<0.01），且在两种组织中5-氟尿嘧啶的浓度与替加氟和尿嘧啶的浓度相关。Dukes分期组和组织学类型与任一组织中替加氟、5-氟尿嘧啶和尿嘧啶的浓度均无关。每种药物在肿瘤组织中的摄取良好且较高。
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