Shimoyama T, Shimizu T, Kusano H, Ishikawa H, Miyashita K, Nakazaki T, Yasutake T, Yoshida A, Yoshida K, Ogawa T
1st Dept. of Surgery, Nagasaki University School of Medicine.
Gan To Kagaku Ryoho. 1993 Jan;20(1):125-30.
In order to elucidate the effect of tumor vascularity on a various regimens concentration in tumor tissue, correlation among tegafur, 5-fluorouracil (5-FU), uracil concentrations in tissue and the microangiography were examined in 27 patients with colorectal cancer after preoperative administration of UFT (400 mg/day for 7 days). The concentrations of tegafur, 5-FU and uracil in tumor were higher than those in normal tissue (p < 0.01). There was no definite correlation between tissue concentration in each regimen and the extra or intramural vascular changes. A significant high concentration of 5-FU was found in the protuberant cancer and the ulcerative cancer with horizontal growth than that in the ulcerative cancer with vertical growth (p < 0.05). The present study indicates that the vascular changes within a tumor and the vascular pattern of tumor may be a contributing factor affecting the tissue concentration in the regimens.
为阐明肿瘤血管生成对肿瘤组织中不同治疗方案药物浓度的影响，我们对27例术前服用优福定（400mg/天，共7天）的结肠癌患者的替加氟、5-氟尿嘧啶（5-FU）、尿嘧啶组织浓度与微血管造影之间的相关性进行了研究。肿瘤组织中替加氟、5-FU和尿嘧啶的浓度高于正常组织（p<0.01）。各治疗方案的组织浓度与壁外或壁内血管变化之间无明确相关性。与垂直生长的溃疡性癌相比，突出型癌和水平生长的溃疡性癌中5-FU浓度显著更高（p<0.05）。本研究表明，肿瘤内的血管变化和肿瘤血管模式可能是影响治疗方案组织浓度的一个因素。
