苯巴比妥和丙戊酸盐用于热性惊厥的随机对照试验。
Randomised controlled trials of phenobarbitone and valproate in febrile convulsions.
作者信息
Newton R W
机构信息
Department of Neurology, Royal Manchester Hospital.
出版信息
Arch Dis Child. 1988 Oct;63(10):1189-91. doi: 10.1136/adc.63.10.1189.
Abstract
Results from British trials of phenobarbitone and valproate for the prophylactic treatment of febrile convulsions were pooled and analysed on an intention to treat basis. The overall odds ratio for phenobarbitone was 0.8 and for valproate 1.42. Neither result was significant. Neither treatment can be recommended in the light of experience.
摘要
英国针对苯巴比妥和丙戊酸盐用于热性惊厥预防性治疗的试验结果进行了汇总，并基于意向性分析原则进行了分析。苯巴比妥的总体比值比为0.8，丙戊酸盐为1.42。两个结果均无统计学意义。根据现有经验，两种治疗方法均不推荐使用。
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本文引用的文献
1
Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial.丙戊酸钠或苯巴比妥持续用药预防“单纯性”热性惊厥：双盲试验比较
Arch Dis Child. 1980 Mar;55(3):171-4. doi: 10.1136/adc.55.3.171.
2
Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone.使用丙戊酸或苯巴比妥成功预防热性惊厥。
Br Med J. 1980 Feb 9;280(6211):353-4. doi: 10.1136/bmj.280.6211.353.
3
Placebo-controlled study of phenobarbitone and phenytoin in the prophylaxis of febrile convulsions.苯巴比妥和苯妥英预防热性惊厥的安慰剂对照研究。
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4
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Br Med J (Clin Res Ed). 1985 Jan 5;290(6461):17-23. doi: 10.1136/bmj.290.6461.17.
5
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Br Med J. 1976 Mar 6;1(6009):559-61. doi: 10.1136/bmj.1.6009.559.
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Sodium valproate in the prophylaxis of simple febrile convulsions.
Clin Pediatr (Phila). 1979 Jul;18(7):426-30. doi: 10.1177/000992287901800710.
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