Int J Gynecol Pathol. 2020 Sep;39(5):456-459. doi: 10.1097/PGP.0000000000000632.
We report a case of vulvar silicone granulomas following injection of liquid silicone into the labia. The patient is a 51-yr-old female who presented with vulvar pain and enlarged, indurated labia majora. In the past, she had undergone bilateral labial cosmetic augmentation with a silicone-based filler injected directly into the labia and into the gluteal regions. This had been performed in a nonmedical setting. At surgery, oblong firm soft tissue masses were removed from both labia. Microscopically, the lesions demonstrated replacement of the subcutaneous adipose tissue by fibrous tissue containing innumerable round empty spaces of different sizes, either within or surrounded by macrophages and occasional foreign-body giant histiocytes. The clear vacuoles corresponded to silicone fluid which had been dissolved during tissue processing. There are only rare case reports of vulvar silicone granuloma in the literature, and these were due to migration of silicone to the vulva from distant sites. Our report details a case of vulvar silicone granuloma secondary to direct injection of liquid silicone material into the labia.
我们报告了一例外阴硅酮肉芽肿，患者因将液态硅酮注射到阴唇而发病。该患者为 51 岁女性，表现为外阴疼痛和阴唇大阴唇增大、变硬。过去，她曾在非医疗环境中接受过双侧阴唇美容填充术，将硅酮基填充物直接注射到阴唇和臀部区域。手术中，从双侧大阴唇切除了长形坚硬的软组织肿块。显微镜下，病变显示皮下脂肪组织被纤维组织取代，纤维组织内含有无数大小不一的圆形空泡，空泡内或周围有巨噬细胞和偶尔的异物巨细胞。这些清晰的空泡对应于在组织处理过程中溶解的硅酮液。文献中仅有少数外阴硅酮肉芽肿的病例报告，这些病例是由于硅酮从远处迁移到外阴。我们的报告详细描述了一例因直接将液态硅酮材料注射到阴唇而导致的外阴硅酮肉芽肿病例。
