Laboratory of Organic and Medicinal Chemistry, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab, 151001, India.
Ira-Ida Skvortsova, Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, Austria.
Curr Drug Targets. 2020;21(3):258-278. doi: 10.2174/1389450120666190821160730.
Resistance to chemotherapy and relapse are major hurdles for the effective treatment of cancer. Major reason for this is a small sub population of cancer stem cells (CSCs) and its microenvironment. CSCs are critical driving force for several types of cancer, such as gastric, colon, breast and many more. Hence, for the complete eradication of cancer, it is necessary to develop therapeutic approaches that can specifically target CSCs. Chemical agents that target different proteins involved in CSC signaling pathways, either as single agent or simultaneously targeting two or more proteins have generated promising pre-clinical and clinical results. In the current review article, we have discussed various targets and cellular pathways that can be explored for the effective and complete eradication of CSCs. Some latest developments in the field of design, synthesis and screening of ligands to target cancer stem cells have been summarized in the current review article.
化疗耐药和复发是癌症有效治疗的主要障碍。主要原因是一小部分癌症干细胞（CSC）及其微环境。CSC 是多种癌症（如胃癌、结肠癌、乳腺癌等）的关键驱动因素。因此，为了彻底清除癌症，有必要开发能够特异性靶向 CSC 的治疗方法。靶向 CSC 信号通路中不同蛋白的化学药物，无论是作为单一药物还是同时靶向两种或多种蛋白，都已经产生了有希望的临床前和临床结果。在这篇综述文章中，我们讨论了可以探索的各种靶标和细胞途径，以有效地彻底清除 CSC。本文综述了针对癌症干细胞的设计、合成和筛选配体领域的一些最新进展。
