Thomas Jörg, Corson Nils I, Meinhold Anke, Both Christian P
Department of Anesthesia, University Children´s Hospital, Zurich, Switzerland.
Department of Anesthesia, University Insel Hospital, Bern, Switzerland.
Paediatr Anaesth. 2019 Oct;29(10):1060-1061. doi: 10.1111/pan.13723. Epub 2019 Aug 30.
While respiratory depression is a known complication of morphine overdose, the neuro-excitatory side effect of the morphine metabolite morphine-3-glucuronide is less widely known. Here, we report the case of an infant with neurological excitation after morphine overdose. The neuro-excitation in this infant was probably induced by an elevated morphine-3-glucuronide concentration.
虽然呼吸抑制是吗啡过量已知的并发症，但吗啡代谢产物吗啡-3-葡糖苷酸的神经兴奋副作用却鲜为人知。在此，我们报告一例吗啡过量后出现神经兴奋的婴儿病例。该婴儿的神经兴奋可能是由吗啡-3-葡糖苷酸浓度升高所致。
