Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3FL, UK.
Department of Dermatology, University of Cologne, Kerpenerstr 62, 50937 Cologne, Germany.
Immunity. 2019 Aug 20;51(2):199-201. doi: 10.1016/j.immuni.2019.07.009.
In this issue of Immunity, Kimball et al. (2019) show that restoring expression of the chromatin modifying enzyme Setdb2 in macrophages rescues impaired wound healing associated with type 2 diabetes. Their findings reveal epigenetic regulation as central to the resolution of macrophage-mediated inflammation in tissue repair and have therapeutic implications for the treatment of diabetic wounds.
在本期《免疫》中，Kimball 等人（2019 年）表明，在巨噬细胞中恢复染色质修饰酶 Setdb2 的表达可以挽救与 2 型糖尿病相关的受损伤口愈合。他们的发现揭示了表观遗传调控在巨噬细胞介导的组织修复炎症消退中的核心作用，这对治疗糖尿病伤口具有治疗意义。
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