Division of Animal Science, Chonnam National University, Gwangju 61186, Republic of Korea.
J Microbiol Biotechnol. 2019 Nov 28;29(11):1745-1748. doi: 10.4014/jmb.1907.07004.
Gamma-aminobutyric acid (GABA) plays important roles in host physiology. However, the effects of GABA are greatly restricted due to its low bioavailability in the human body. Here, a high acid-tolerance GABA-producing strain, Bmb5, was isolated from kimchi. Bmb5 converted glutamate to GABA (7.23 ± 0.68 µg/µl) at a rate of 72.3%. The expression of gene, encoding the enzyme involved in the decarboxylation of glutamate to GABA, was decreased upon incubation. Our findings indicate GABA production in Bmb5 is not directly correlated with gene expression, providing new insight into the mechanisms underlying GABA production in .
γ-氨基丁酸（GABA）在宿主生理学中发挥着重要作用。然而，由于其在人体内的生物利用度低，GABA 的作用受到了极大的限制。在这里，从泡菜中分离到了一株具有高耐酸性的 GABA 产生菌 Bmb5。Bmb5 将谷氨酸转化为 GABA 的速度为 72.3%（7.23±0.68μg/μl）。在孵育过程中，编码参与谷氨酸脱羧生成 GABA 的酶的 基因的表达下降。我们的研究结果表明，Bmb5 中的 GABA 产生与 基因表达没有直接关系，为 GABA 产生的机制提供了新的见解。
